Literature DB >> 22817467

Mitochondria-targeted antioxidant SkQR1 ameliorates gentamycin-induced renal failure and hearing loss.

S S Jankauskas1, E Y Plotnikov, M A Morosanova, I B Pevzner, L D Zorova, V P Skulachev, D B Zorov.   

Abstract

The influence of the mitochondria-targeted antioxidant SkQR1 on gentamycin-induced nephrotoxicity and ototoxicity has been analyzed. SkQR1 reduces the death of kidney epithelium cells and decreases the severity of renal failure caused by gentamycin application and also lowers the animals' mortality. Treatment with SkQR1 also decreases gentamycin-induced hearing loss. Mitochondria-targeted antioxidants, such as SkQR1, are new promising agents for preventing negative consequences of therapy with antibiotics.

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Year:  2012        PMID： 22817467     DOI： 10.1134/S0006297912060144

Source DB:  PubMed          Journal:  Biochemistry (Mosc)        ISSN： 0006-2979            Impact factor:   2.487


  15 in total

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Journal:  Physiol Rev       Date:  2014-07       Impact factor: 37.312

2.  New trends in aminoglycosides use.

Authors:  Marina Y Fosso; Yijia Li; Sylvie Garneau-Tsodikova
Journal:  Medchemcomm       Date:  2014-08-01       Impact factor: 3.597

3.  Assessment of nutrient supplement to reduce gentamicin-induced ototoxicity.

Authors:  C G Le Prell; C Ojano-Dirain; E W Rudnick; M A Nelson; S J DeRemer; D M Prieskorn; J M Miller
Journal:  J Assoc Res Otolaryngol       Date:  2014-03-04

Review 4.  The Emerging Role of Mitochondrial Targeting in Kidney Disease.

Authors:  Alfonso Eirin; Amir Lerman; Lilach O Lerman
Journal:  Handb Exp Pharmacol       Date:  2017

5.  Aged kidney: can we protect it? Autophagy, mitochondria and mechanisms of ischemic preconditioning.

Authors:  Stanislovas S Jankauskas; Denis N Silachev; Nadezda V Andrianova; Irina B Pevzner; Ljubava D Zorova; Vasily A Popkov; Egor Y Plotnikov; Dmitry B Zorov
Journal:  Cell Cycle       Date:  2018-07-25       Impact factor: 4.534

6.  Mechanisms and pharmacokinetic/pharmacodynamic profiles underlying the low nephrotoxicity and ototoxicity of etimicin.

Authors:  Lan Yao; Jing-Wei Zhang; Bin Chen; Ming-Min Cai; Dong Feng; Qi-Zhi Wang; Xin-Yu Wang; Jian-Guo Sun; Yi-Wen Zheng; Guang-Ji Wang; Fang Zhou
Journal:  Acta Pharmacol Sin       Date:  2020-01-14       Impact factor: 6.150

7.  Intermittent exposure to xenon protects against gentamicin-induced nephrotoxicity.

Authors:  Ping Jia; Jie Teng; Jianzhou Zou; Yi Fang; Suhua Jiang; Xiaofang Yu; Alison J Kriegel; Mingyu Liang; Xiaoqiang Ding
Journal:  PLoS One       Date:  2013-05-30       Impact factor: 3.240

Review 8.  Mitochondria-Targeted Antioxidants: Future Perspectives in Kidney Ischemia Reperfusion Injury.

Authors:  Aleksandra Kezic; Ivan Spasojevic; Visnja Lezaic; Milica Bajcetic
Journal:  Oxid Med Cell Longev       Date:  2016-05-24       Impact factor: 6.543

9.  The targeted anti-oxidant MitoQ causes mitochondrial swelling and depolarization in kidney tissue.

Authors:  Esther M Gottwald; Michael Duss; Milica Bugarski; Dominik Haenni; Claus D Schuh; Ehud M Landau; Andrew M Hall
Journal:  Physiol Rep       Date:  2018-04

10.  Mitochondria-Targeted Antioxidant SkQ1 Prevents Anesthesia-Induced Dry Eye Syndrome.

Authors:  Evgeni Yu Zernii; Olga S Gancharova; Viktoriia E Baksheeva; Marina O Golovastova; Ekaterina I Kabanova; Marina S Savchenko; Veronika V Tiulina; Larisa F Sotnikova; Andrey A Zamyatnin; Pavel P Philippov; Ivan I Senin
Journal:  Oxid Med Cell Longev       Date:  2017-10-12       Impact factor: 6.543
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