| Literature DB >> 22816614 |
Andishe Attarbaschi1, Maria Morak, Gunnar Cario, Giovanni Cazzaniga, Hannah M Ensor, Truus te Kronnie, Jutta Bradtke, Georg Mann, Elena Vendramini, Chiara Palmi, Claire Schwab, Lisa J Russell, Martin Schrappe, Valentino Conter, Christopher D Mitchell, Sabine Strehl, Martin Zimmermann, Ulrike Pötschger, Christine J Harrison, Martin Stanulla, Renate Panzer-Grümayer, Oskar A Haas, Anthony V Moorman.
Abstract
The prognostic relevance of CRLF2 -rearrangements in childhood acute B-cell precursor lymphoblastic leukaemia (ALL), was assessed by a comparative analysis of 114 non-Down-syndrome patients (99 P2RY8-CRLF2+ , 15 IGH@-CRLF2+ ), 76 from the AIEOP-BFM ALL 2000 and 38 from the MRC ALL97 trials. The 6-year cumulative relapse incidence of P2RY8-CRLF2+ patients treated on the two trials was not statistically different: 0·37 ± 0·06 vs. 0·25 ± 0·08 (P = 0·194). In contrast, 0/9 IGH@-CRLF2+ AIEOP-BFM, but 5/6 ALL97 patients relapsed. Conclusively, P2RY8-CRLF2+ patients had an intermediate protocol-independent outcome while the different prognosis of IGH@-CRLF2+ patients could be related to the different structures of the applied treatment protocols.Entities:
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Year: 2012 PMID： 22816614 DOI： 10.1111/j.1365-2141.2012.09221.x
Source DB: PubMed Journal: Br J Haematol ISSN： 0007-1048 Impact factor: 6.998