Literature DB >> 22814344

Negative regulators take center stage.

Silvia Monticelli1, Federica Sallusto.   

Abstract

The transcription factor Aiolos is upregulated in T lymphocytes in a manner dependent on the transcription factors STAT3 and AhR and leads to epigenetic silencing of the gene encoding interleukin 2. This acts as a cell-intrinsic safeguard mechanism for the differentiation of helper T cells into the TH17 subset.

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Year:  2012        PMID： 22814344     DOI： 10.1038/ni.2377

Source DB:  PubMed          Journal:  Nat Immunol        ISSN： 1529-2908            Impact factor:   25.606


  11 in total

1.  Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5.

Authors:  Xiang-Ping Yang; Kamran Ghoreschi; Scott M Steward-Tharp; Jaime Rodriguez-Canales; Jinfang Zhu; John R Grainger; Kiyoshi Hirahara; Hong-Wei Sun; Lai Wei; Golnaz Vahedi; Yuka Kanno; John J O'Shea; Arian Laurence
Journal:  Nat Immunol       Date:  2011-01-30       Impact factor: 25.606

2.  Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells.

Authors:  Roopali Gandhi; Deepak Kumar; Evan J Burns; Meghan Nadeau; Ben Dake; Alice Laroni; Deneen Kozoriz; Howard L Weiner; Francisco J Quintana
Journal:  Nat Immunol       Date:  2010-08-01       Impact factor: 25.606

Review 3.  The role of interleukin-2 during homeostasis and activation of the immune system.

Authors:  Onur Boyman; Jonathan Sprent
Journal:  Nat Rev Immunol       Date:  2012-02-17       Impact factor: 53.106

4.  Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β.

Authors:  Christina E Zielinski; Federico Mele; Dominik Aschenbrenner; David Jarrossay; Francesca Ronchi; Marco Gattorno; Silvia Monticelli; Antonio Lanzavecchia; Federica Sallusto
Journal:  Nature       Date:  2012-04-26       Impact factor: 49.962

Review 5.  Genomic views of STAT function in CD4+ T helper cell differentiation.

Authors:  John J O'Shea; Riitta Lahesmaa; Golnaz Vahedi; Arian Laurence; Yuka Kanno
Journal:  Nat Rev Immunol       Date:  2011-04       Impact factor: 53.106

6.  Aiolos promotes TH17 differentiation by directly silencing Il2 expression.

Authors:  Francisco J Quintana; Hulin Jin; Evan J Burns; Meghan Nadeau; Ada Yeste; Deepak Kumar; Manu Rangachari; Chen Zhu; Sheng Xiao; John Seavitt; Katia Georgopoulos; Vijay K Kuchroo
Journal:  Nat Immunol       Date:  2012-07-01       Impact factor: 25.606

7.  TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology.

Authors:  Mandy J McGeachy; Kristian S Bak-Jensen; Yi Chen; Cristina M Tato; Wendy Blumenschein; Terrill McClanahan; Daniel J Cua
Journal:  Nat Immunol       Date:  2007-11-11       Impact factor: 25.606

Review 8.  An epigenetic view of helper T cell differentiation.

Authors:  K Mark Ansel; Dong U Lee; Anjana Rao
Journal:  Nat Immunol       Date:  2003-07       Impact factor: 25.606

9.  Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells.

Authors:  Fan Pan; Hong Yu; Eric V Dang; Joseph Barbi; Xiaoyu Pan; Joseph F Grosso; Dinili Jinasena; Sudarshana M Sharma; Erin M McCadden; Derese Getnet; Charles G Drake; Jun O Liu; Michael C Ostrowski; Drew M Pardoll
Journal:  Science       Date:  2009-08-20       Impact factor: 47.728

10.  Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling.

Authors:  Kamran Ghoreschi; Arian Laurence; Xiang-Ping Yang; Cristina M Tato; Mandy J McGeachy; Joanne E Konkel; Haydeé L Ramos; Lai Wei; Todd S Davidson; Nicolas Bouladoux; John R Grainger; Qian Chen; Yuka Kanno; Wendy T Watford; Hong-Wei Sun; Gérard Eberl; Ethan M Shevach; Yasmine Belkaid; Daniel J Cua; Wanjun Chen; John J O'Shea
Journal:  Nature       Date:  2010-10-21       Impact factor: 49.962
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  2 in total

1.  The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins.

Authors:  Gang Lu; Richard E Middleton; Huahang Sun; MarkVic Naniong; Christopher J Ott; Constantine S Mitsiades; Kwok-Kin Wong; James E Bradner; William G Kaelin
Journal:  Science       Date:  2013-11-29       Impact factor: 47.728

2.  Benzyl butyl phthalate induces migration, invasion, and angiogenesis of Huh7 hepatocellular carcinoma cells through nongenomic AhR/G-protein signaling.

Authors:  Cheng-Fang Tsai; Tsung-Hua Hsieh; Jau-Nan Lee; Chia-Yi Hsu; Yu-Chih Wang; Feng-Jie Lai; Kung-Kai Kuo; Hua-Lin Wu; Eing-Mei Tsai; Po-Lin Kuo
Journal:  BMC Cancer       Date:  2014-08-01       Impact factor: 4.430
  2 in total

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