BACKGROUND/AIMS: Delusions in Alzheimer's disease (AD) may be associated with functional impairment. No studies to date have used functional instruments sensitive to changes in frontal executive function, possibly underestimating the impact. METHODS: Patients with AD with and without delusions were administered cognitive tests and questionnaires to assess depression and quality of life. Caregivers were administered questionnaires to assess functional impairment, caregiver burden and behavioural symptoms. RESULTS: AD patients with delusions (n = 19) when compared to AD patients without delusions (n = 19) matched for age, education and global cognitive function were significantly more functionally impaired based on performance on the Disability Assessment for Dementia Scale (p < 0.005). CONCLUSION: AD patients with delusions have significantly worse functional performance.
BACKGROUND/AIMS: Delusions in Alzheimer's disease (AD) may be associated with functional impairment. No studies to date have used functional instruments sensitive to changes in frontal executive function, possibly underestimating the impact. METHODS:Patients with AD with and without delusions were administered cognitive tests and questionnaires to assess depression and quality of life. Caregivers were administered questionnaires to assess functional impairment, caregiver burden and behavioural symptoms. RESULTS:ADpatients with delusions (n = 19) when compared to ADpatients without delusions (n = 19) matched for age, education and global cognitive function were significantly more functionally impaired based on performance on the Disability Assessment for Dementia Scale (p < 0.005). CONCLUSION:ADpatients with delusions have significantly worse functional performance.
Authors: Corinne E Fischer; Winnie Qian; Tom A Schweizer; Colleen P Millikin; Zahinoor Ismail; Eric E Smith; Lisa M Lix; Paul Shelton; David G Munoz Journal: J Alzheimers Dis Date: 2016 Impact factor: 4.472
Authors: Winnie Qian; Tom A Schweizer; Nathan W Churchill; Colleen Millikin; Zahinoor Ismail; Eric E Smith; Lisa M Lix; David G Munoz; Joseph J Barfett; Tarek K Rajji; Corinne E Fischer Journal: Am J Geriatr Psychiatry Date: 2018-10-02 Impact factor: 4.105
Authors: Zahinoor Ismail; Eric E Smith; Yonas Geda; David Sultzer; Henry Brodaty; Gwenn Smith; Luis Agüera-Ortiz; Rob Sweet; David Miller; Constantine G Lyketsos Journal: Alzheimers Dement Date: 2015-06-18 Impact factor: 21.566
Authors: Corinne E Fischer; Windsor Kwan-Chun Ting; Colleen P Millikin; Zahinoor Ismail; Tom A Schweizer Journal: Int J Geriatr Psychiatry Date: 2015-03-27 Impact factor: 3.485
Authors: Zahinoor Ismail; Luis Agüera-Ortiz; Henry Brodaty; Alicja Cieslak; Jeffrey Cummings; Corinne E Fischer; Serge Gauthier; Yonas E Geda; Nathan Herrmann; Jamila Kanji; Krista L Lanctôt; David S Miller; Moyra E Mortby; Chiadi U Onyike; Paul B Rosenberg; Eric E Smith; Gwenn S Smith; David L Sultzer; Constantine Lyketsos Journal: J Alzheimers Dis Date: 2017 Impact factor: 4.472
Authors: Zahinoor Ismail; Byron Creese; Dag Aarsland; Helen C Kales; Constantine G Lyketsos; Robert A Sweet; Clive Ballard Journal: Nat Rev Neurol Date: 2022-01-04 Impact factor: 44.711