BACKGROUND AND PURPOSE: More evidence is needed to forward our understanding of the key determinants of poor outcome after mild traumatic brain injury (MTBI). A large, prospective, national cohort of patients was studied to analyse the effect of head CT scan pathology on the outcome. METHODS: One-thousand two-hundred and sixty-two patients with MTBI (Glasgow Coma Scale score 15) at 39 emergency departments completed a study protocol including acute head CT scan examination and follow-up by the Rivermead Post Concussion Symptoms Questionnaire and the Glasgow Outcome Scale Extended (GOSE) at 3 months after MTBI. Binary logistic regression was used for the assessment of prediction ability. RESULTS: In 751 men (60%) and 511 women (40%), with a mean age of 30 years (median 21, range 6-94), we observed relevant or suspect relevant pathologic findings on acute CT scan in 52 patients (4%). Patients aged below 30 years reported better outcome both with respect to symptoms and GOSE as compared to patients in older age groups. Men reported better outcome than women as regards symptoms (OR 0.64, CI 0.49-0.85 for ≥3 symptoms) and global function (OR 0.60, CI 0.39-0.92 for GOSE 1-6). CONCLUSIONS: Pathology on acute CT scan examination had no effect on self-reported symptoms or global function at 3 months after MTBI. Female gender and older age predicted a less favourable outcome. The findings support the view that other factors than brain injury deserve attention to minimize long-term complaints after MTBI.
BACKGROUND AND PURPOSE: More evidence is needed to forward our understanding of the key determinants of poor outcome after mild traumatic brain injury (MTBI). A large, prospective, national cohort of patients was studied to analyse the effect of head CT scan pathology on the outcome. METHODS: One-thousand two-hundred and sixty-two patients with MTBI (Glasgow Coma Scale score 15) at 39 emergency departments completed a study protocol including acute head CT scan examination and follow-up by the Rivermead Post Concussion Symptoms Questionnaire and the Glasgow Outcome Scale Extended (GOSE) at 3 months after MTBI. Binary logistic regression was used for the assessment of prediction ability. RESULTS: In 751 men (60%) and 511 women (40%), with a mean age of 30 years (median 21, range 6-94), we observed relevant or suspect relevant pathologic findings on acute CT scan in 52 patients (4%). Patients aged below 30 years reported better outcome both with respect to symptoms and GOSE as compared to patients in older age groups. Men reported better outcome than women as regards symptoms (OR 0.64, CI 0.49-0.85 for ≥3 symptoms) and global function (OR 0.60, CI 0.39-0.92 for GOSE 1-6). CONCLUSIONS: Pathology on acute CT scan examination had no effect on self-reported symptoms or global function at 3 months after MTBI. Female gender and older age predicted a less favourable outcome. The findings support the view that other factors than brain injury deserve attention to minimize long-term complaints after MTBI.
Authors: Vignesh Subbian; Jonathan J Ratcliff; Jason M Meunier; Joseph J Korfhagen; Fred R Beyette; George J Shaw Journal: IEEE J Transl Eng Health Med Date: 2015-04-23 Impact factor: 3.316
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Authors: Vignesh Subbian; Jonathan J Ratcliff; Joseph J Korfhagen; Kimberly W Hart; Jason M Meunier; George J Shaw; Christopher J Lindsell; Fred R Beyette Journal: Acad Emerg Med Date: 2016-03-21 Impact factor: 3.451
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Authors: Aleksandra Karolina Gozt; Sarah Claire Hellewell; Jacinta Thorne; Elizabeth Thomas; Francesca Buhagiar; Shaun Markovic; Anoek Van Houselt; Alexander Ring; Glenn Arendts; Ben Smedley; Sjinene Van Schalkwyk; Philip Brooks; John Iliff; Antonio Celenza; Ashes Mukherjee; Dan Xu; Suzanne Robinson; Stephen Honeybul; Gill Cowen; Melissa Licari; Michael Bynevelt; Carmela F Pestell; Daniel Fatovich; Melinda Fitzgerald Journal: BMJ Open Date: 2021-05-13 Impact factor: 2.692
Authors: William J Panenka; Rael T Lange; Sylvain Bouix; Jason R Shewchuk; Manraj K S Heran; Jeffrey R Brubacher; Ryan Eckbo; Martha E Shenton; Grant L Iverson Journal: PLoS One Date: 2015-04-27 Impact factor: 3.240