Literature DB >> 22812501

Continuous-flow synthesis of monoarylated acetaldehydes using aryldiazonium salts.

Natalia Chernyak1, Stephen L Buchwald.   

Abstract

Anilines and ethyl vinyl ether can be used as precursors for a process that is the synthetic equivalent of the α-arylation of acetaldehyde enolate. The reaction manifests a high level of functional group compatibility, allowing the ready preparation of a number of synthetically valuable compounds.

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Year:  2012        PMID： 22812501     DOI： 10.1021/ja305660a

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  8 in total

1.  Radical Hydroarylation of Functionalized Olefins and Mechanistic Investigation of Photocatalytic Pyridyl Radical Reactions.

Authors:  Ciaran P Seath; David B Vogt; Zihao Xu; Allyson J Boyington; Nathan T Jui
Journal:  J Am Chem Soc       Date:  2018-11-05       Impact factor: 15.419

2.  Rapid and efficient trifluoromethylation of aromatic and heteroaromatic compounds using potassium trifluoroacetate enabled by a flow system.

Authors:  Mao Chen; Stephen L Buchwald
Journal:  Angew Chem Int Ed Engl       Date:  2013-09-05       Impact factor: 15.336

3.  Design of a novel thiophene inhibitor of 15-lipoxygenase-1 with both anti-inflammatory and neuroprotective properties.

Authors:  Niek G J Leus; Birgit Honrath; Nikolaos Eleftheriadis; Hessel Poelman; Constantinos G Neochoritis; Amalia Dolga; Alexander Dömling; Frank J Dekker
Journal:  Eur J Med Chem       Date:  2016-07-09       Impact factor: 6.514

4.  Efficient synthesis of 3H-indoles enabled by the lead-mediated α-arylation of β-ketoesters or γ-lactams using aryl azides.

Authors:  Fei Zhou; Tom G Driver
Journal:  Org Lett       Date:  2014-05-27       Impact factor: 6.005

Review 5.  Automating multistep flow synthesis: approach and challenges in integrating chemistry, machines and logic.

Authors:  Chinmay A Shukla; Amol A Kulkarni
Journal:  Beilstein J Org Chem       Date:  2017-05-19       Impact factor: 2.883

6.  Polysubstituted ferrocenes as tunable redox mediators.

Authors:  Sven D Waniek; Jan Klett; Christoph Förster; Katja Heinze
Journal:  Beilstein J Org Chem       Date:  2018-05-07       Impact factor: 2.883

7.  A mild, ferrocene-catalyzed C-H imidation of (hetero)arenes.

Authors:  Klement Foo; Eran Sella; Isabelle Thomé; Martin D Eastgate; Phil S Baran
Journal:  J Am Chem Soc       Date:  2014-03-31       Impact factor: 15.419

8.  In Situ FTIR Spectroscopic Monitoring of the Formation of the Arene Diazonium Salts and its Applications to the Heck-Matsuda Reaction.

Authors:  K Sateesh Reddy; Bandi Siva; S Divya Reddy; N Reddy Naresh; T V Pratap; B Venkateswara Rao; Yi-An Hong; B Vijaya Kumar; A Krishnam Raju; P Muralidhar Reddy; Anren Hu
Journal:  Molecules       Date:  2020-05-08       Impact factor: 4.411
  8 in total

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