F Qian1, Q Zhang, L Zhou, G Ma, G Jin, Q Huang, K Yin. 1. Department of Respiratory Medicine, Affiliated Hospital, Jiangsu University, Zhenjiang, Jiangsu, China. zhaoqian604@yahoo.com.cn
Abstract
BACKGROUND AND OBJECTIVES: Interleukin (IL) 17F is a marker of type 17 helper T cells and has a proinflammatory role in asthma.The aim of the present study was to assess the possible association between asthma and polymorphisms in the IL17F gene in a Chinese population. METHODS: A total of 318 asthmatic patients and 352 nonasthmatic controls were recruited. Two single-nucleotide polymorphisms in IL17F (rs763780 and rs13209590) were detected using GenomeLab SNPstream. Logistic regression methods were used to analyze data. RESULTS: A significantly lower frequency of the C allele in rs763780 was observed in the control group (P = .0148). The rs763780 TC heterozygote was associated with an increased risk of asthma, and a similar trend was observed assuming a codominant genotype effect (adjusted OR, 1.58; 95% CI, 1.06-2.36; P = .0148; adjusted OR, 1.64; 95% CI, 1.10-2.45; P = .0217). Furthermore, a novel finding of the present study was that this association was exclusive to males (adjusted OR, 1.79; 95% CI, 1.06-3.05; P = .0308) and patients with higher immunoglobulin E levels (> or = 1.85 IU/mL) (adjusted OR, 1.88; 95% CI, 1.10-3.22; P = .0213). We also found that the haplotype with minor alleles for rs763780 was associated with an increased risk of asthma (adjusted OR, 1.62; 95% CI, 1.11-2.35; P = .0115). CONCLUSION: Our findings indicated that polymorphisms might play a role in susceptibility to asthma.
BACKGROUND AND OBJECTIVES:Interleukin (IL) 17F is a marker of type 17 helper T cells and has a proinflammatory role in asthma.The aim of the present study was to assess the possible association between asthma and polymorphisms in the IL17F gene in a Chinese population. METHODS: A total of 318 asthmatic patients and 352 nonasthmatic controls were recruited. Two single-nucleotide polymorphisms in IL17F (rs763780 and rs13209590) were detected using GenomeLab SNPstream. Logistic regression methods were used to analyze data. RESULTS: A significantly lower frequency of the C allele in rs763780 was observed in the control group (P = .0148). The rs763780 TC heterozygote was associated with an increased risk of asthma, and a similar trend was observed assuming a codominant genotype effect (adjusted OR, 1.58; 95% CI, 1.06-2.36; P = .0148; adjusted OR, 1.64; 95% CI, 1.10-2.45; P = .0217). Furthermore, a novel finding of the present study was that this association was exclusive to males (adjusted OR, 1.79; 95% CI, 1.06-3.05; P = .0308) and patients with higher immunoglobulin E levels (> or = 1.85 IU/mL) (adjusted OR, 1.88; 95% CI, 1.10-3.22; P = .0213). We also found that the haplotype with minor alleles for rs763780 was associated with an increased risk of asthma (adjusted OR, 1.62; 95% CI, 1.11-2.35; P = .0115). CONCLUSION: Our findings indicated that polymorphisms might play a role in susceptibility to asthma.
Authors: A Batalla; E Coto; J Gómez; N Eirís; D González-Fernández; C Gómez-De Castro; E Daudén; M Llamas-Velasco; R Prieto-Perez; F Abad-Santos; G Carretero; F S García; Y B Godoy; L F Cardo; B Alonso; S Iglesias; P Coto-Segura Journal: Pharmacogenomics J Date: 2016-09-27 Impact factor: 3.550
Authors: Katarzyna Bogunia-Kubik; Jerzy Świerkot; Anna Malak; Barbara Wysoczańska; Beata Nowak; Katarzyna Białowąs; Katarzyna Gębura; Lucyna Korman; Piotr Wiland Journal: Arch Immunol Ther Exp (Warsz) Date: 2014-11-12 Impact factor: 4.291