BACKGROUND AND AIMS: The relation of -55C/T polymorphism of uncoupling protein 3 (UCP3) with metabolic syndrome (MS) has been evaluated only in one previous study with contradictory results. The aim of our study was to investigate the association of -55C/T polymorphism of UCP3 gene with MS. DESIGN: A population of 817 obese Caucasian patients was analyzed in a cross-sectional survey. Genotype of UCP3 gene -55C/T was studied. To estimate the prevalence of MS , the definitions of the ATPIII were considered. RESULTS: Five hundred and ninety-four patients (72.7%) had the genotype -55CC (wild group), whereas 223 patients (27.3%) had the genotype -55C/T. Genotype -5TT was not detected. Prevalence of mutant UCP genotypes was similar in patients with MS (75.7% wild genotype and 24.3% mutant genotype) and without MS (69.7% wild genotype and 30.3% mutant genotype). Odds ratio of MS wild vs. mutant genotype was 1.17 CI 95%: 0.99-1.38). Total cholesterol and low density lipoprotein (LDL) cholesterol concentrations were lower in mutant-type group than wild-type group in patients with MS. No differences in other parameters were detected between genotypes in the same group of MS. CONCLUSION: -55C/T UCP polymorphism is not major risk factor for the MS. However, in mutant group of -55CC UCP3 gene in patients with MS, total cholesterol and LDL cholesterol were lower than wild-type patients.
BACKGROUND AND AIMS: The relation of -55C/T polymorphism of uncoupling protein 3 (UCP3) with metabolic syndrome (MS) has been evaluated only in one previous study with contradictory results. The aim of our study was to investigate the association of -55C/T polymorphism of UCP3 gene with MS. DESIGN: A population of 817 obese Caucasian patients was analyzed in a cross-sectional survey. Genotype of UCP3 gene -55C/T was studied. To estimate the prevalence of MS , the definitions of the ATPIII were considered. RESULTS: Five hundred and ninety-four patients (72.7%) had the genotype -55CC (wild group), whereas 223 patients (27.3%) had the genotype -55C/T. Genotype -5TT was not detected. Prevalence of mutant UCP genotypes was similar in patients with MS (75.7% wild genotype and 24.3% mutant genotype) and without MS (69.7% wild genotype and 30.3% mutant genotype). Odds ratio of MS wild vs. mutant genotype was 1.17 CI 95%: 0.99-1.38). Total cholesterol and low density lipoprotein (LDL) cholesterol concentrations were lower in mutant-type group than wild-type group in patients with MS. No differences in other parameters were detected between genotypes in the same group of MS. CONCLUSION:-55C/TUCP polymorphism is not major risk factor for the MS. However, in mutant group of -55CC UCP3 gene in patients with MS, total cholesterol and LDL cholesterol were lower than wild-type patients.
Authors: J C Clapham; J R Arch; H Chapman; A Haynes; C Lister; G B Moore; V Piercy; S A Carter; I Lehner; S A Smith; L J Beeley; R J Godden; N Herrity; M Skehel; K K Changani; P D Hockings; D G Reid; S M Squires; J Hatcher; B Trail; J Latcham; S Rastan; A J Harper; S Cadenas; J A Buckingham; M D Brand; A Abuin Journal: Nature Date: 2000-07-27 Impact factor: 49.962
Authors: Christian-Marc Lanouette; Yvon C Chagnon; Treva Rice; Louis Pérusse; Patrick Muzzin; Jean-Paul Giacobino; Jacques Gagnon; Jack H Wilmore; Arthur S Leon; James S Skinner; D C Rao; Claude Bouchard Journal: J Appl Physiol (1985) Date: 2002-03
Authors: L T Dalgaard; T I Sørensen; T Drivsholm; K Borch-Johnsen; T Andersen; T Hansen; O Pedersen Journal: J Clin Endocrinol Metab Date: 2001-03 Impact factor: 5.958
Authors: Alvaro Alonso; Amelia Martí; María Soledad Corbalán; Miguel A Martínez-González; Luis Forga; J Alfredo Martínez Journal: Ann Nutr Metab Date: 2005-07-07 Impact factor: 3.374
Authors: María C Ochoa; José L Santos; Cristina Azcona; María J Moreno-Aliaga; Miguel A Martínez-González; J Alfredo Martínez; Amelia Marti Journal: Mol Genet Metab Date: 2007-09-17 Impact factor: 4.797
Authors: D A de Luis; D Pacheco; R Aller; M González Sagrado; O Izaola; M C Terroba; L Cuellar; R Conde; T Martin; J L Perez Castrillon Journal: Obes Surg Date: 2008-05-17 Impact factor: 4.129