Literature DB >> 22810762

Where have all the active receptor states gone?

H Ongun Onaran1, Tommaso Costa.   

Abstract

Defining G protein-coupled receptor ligand efficacy and biased agonism in precise chemical terms is one challenge posed by the current structural data that exists for this receptor family. Concepts classically used for understanding enzymes and other nonreceptor proteins may lead us in the right direction.

Mesh：

Substances：

Year:  2012        PMID： 22810762     DOI： 10.1038/nchembio.1024

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


  24 in total

1.  Can allosteric regulation be predicted from structure?

Authors:  E Freire
Journal:  Proc Natl Acad Sci U S A       Date:  2000-10-24       Impact factor: 11.205

Review 2.  Update 1 of: computational modeling approaches to structure-function analysis of G protein-coupled receptors.

Authors:  Francesca Fanelli; Pier G De Benedetti
Journal:  Chem Rev       Date:  2011-12-14       Impact factor: 60.622

3.  Allosteric coupling and conformational fluctuations in proteins.

Authors:  H Ongun Onaran; Tommaso Costa
Journal:  Curr Protein Pept Sci       Date:  2009-04       Impact factor: 3.272

Review 4.  Allostery and cooperativity revisited.

Authors:  Qiang Cui; Martin Karplus
Journal:  Protein Sci       Date:  2008-06-17       Impact factor: 6.725

5.  Structure of an agonist-bound human A2A adenosine receptor.

Authors:  Fei Xu; Huixian Wu; Vsevolod Katritch; Gye Won Han; Kenneth A Jacobson; Zhan-Guo Gao; Vadim Cherezov; Raymond C Stevens
Journal:  Science       Date:  2011-03-10       Impact factor: 47.728

6.  Allostery without conformational change. A plausible model.

Authors:  A Cooper; D T Dryden
Journal:  Eur Biophys J       Date:  1984       Impact factor: 1.733

7.  The structural basis for agonist and partial agonist action on a β(1)-adrenergic receptor.

Authors:  Tony Warne; Rouslan Moukhametzianov; Jillian G Baker; Rony Nehmé; Patricia C Edwards; Andrew G W Leslie; Gebhard F X Schertler; Christopher G Tate
Journal:  Nature       Date:  2011-01-13       Impact factor: 49.962

8.  Structure and function of an irreversible agonist-β(2) adrenoceptor complex.

Authors:  Daniel M Rosenbaum; Cheng Zhang; Joseph A Lyons; Ralph Holl; David Aragao; Daniel H Arlow; Søren G F Rasmussen; Hee-Jung Choi; Brian T Devree; Roger K Sunahara; Pil Seok Chae; Samuel H Gellman; Ron O Dror; David E Shaw; William I Weis; Martin Caffrey; Peter Gmeiner; Brian K Kobilka
Journal:  Nature       Date:  2011-01-13       Impact factor: 49.962

9.  Crystal structure of the β2 adrenergic receptor-Gs protein complex.

Authors:  Søren G F Rasmussen; Brian T DeVree; Yaozhong Zou; Andrew C Kruse; Ka Young Chung; Tong Sun Kobilka; Foon Sun Thian; Pil Seok Chae; Els Pardon; Diane Calinski; Jesper M Mathiesen; Syed T A Shah; Joseph A Lyons; Martin Caffrey; Samuel H Gellman; Jan Steyaert; Georgios Skiniotis; William I Weis; Roger K Sunahara; Brian K Kobilka
Journal:  Nature       Date:  2011-07-19       Impact factor: 49.962

Review 10.  Protein allostery, signal transmission and dynamics: a classification scheme of allosteric mechanisms.

Authors:  Chung-Jung Tsai; Antonio Del Sol; Ruth Nussinov
Journal:  Mol Biosyst       Date:  2009-01-06
View more
  13 in total

Review 1.  Signalling bias in new drug discovery: detection, quantification and therapeutic impact.

Authors:  Terry Kenakin; Arthur Christopoulos
Journal:  Nat Rev Drug Discov       Date:  2012-02-15       Impact factor: 84.694

2.  Detection of G protein-selective G protein-coupled receptor (GPCR) conformations in live cells.

Authors:  Rabia U Malik; Michael Ritt; Brian T DeVree; Richard R Neubig; Roger K Sunahara; Sivaraj Sivaramakrishnan
Journal:  J Biol Chem       Date:  2013-04-29       Impact factor: 5.157

Review 3.  Identifying ligand-specific signalling within biased responses: focus on δ opioid receptor ligands.

Authors:  I Charfi; N Audet; H Bagheri Tudashki; G Pineyro
Journal:  Br J Pharmacol       Date:  2014-07-01       Impact factor: 8.739

Review 4.  Molecular Pharmacology of δ-Opioid Receptors.

Authors:  Louis Gendron; Catherine M Cahill; Mark von Zastrow; Peter W Schiller; Graciela Pineyro
Journal:  Pharmacol Rev       Date:  2016-07       Impact factor: 25.468

5.  G Protein-selective GPCR Conformations Measured Using FRET Sensors in a Live Cell Suspension Fluorometer Assay.

Authors:  Ansley Semack; Rabia U Malik; Sivaraj Sivaramakrishnan
Journal:  J Vis Exp       Date:  2016-09-10       Impact factor: 1.355

6.  Allosteric modulation of β-arrestin-biased angiotensin II type 1 receptor signaling by membrane stretch.

Authors:  Wei Tang; Ryan T Strachan; Robert J Lefkowitz; Howard A Rockman
Journal:  J Biol Chem       Date:  2014-08-28       Impact factor: 5.157

7.  Label-free cell phenotypic assessment of the biased agonism and efficacy of agonists at the endogenous muscarinic M3 receptors.

Authors:  Huayun Deng; Haiyan Sun; Ye Fang
Journal:  J Pharmacol Toxicol Methods       Date:  2013-08-09       Impact factor: 1.950

8.  Retinal Conformation Changes Rhodopsin's Dynamic Ensemble.

Authors:  Nicholas Leioatts; Tod D Romo; Shairy Azmy Danial; Alan Grossfield
Journal:  Biophys J       Date:  2015-08-04       Impact factor: 4.033

9.  Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR).

Authors:  Ryan T Strachan; Jin-peng Sun; David H Rominger; Jonathan D Violin; Seungkirl Ahn; Alex Rojas Bie Thomsen; Xiao Zhu; Andrew Kleist; Tommaso Costa; Robert J Lefkowitz
Journal:  J Biol Chem       Date:  2014-03-25       Impact factor: 5.157

Review 10.  Recent developments in biased agonism.

Authors:  James W Wisler; Kunhong Xiao; Alex R B Thomsen; Robert J Lefkowitz
Journal:  Curr Opin Cell Biol       Date:  2013-11-20       Impact factor: 8.382
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.