BACKGROUND: Obesity is a chronic disease defined by an excess amount of adipose tissue and presents a low-grade inflammatory state, increasing cardiovascular risk. OBJECTIVE: To assess the effect of weight loss magnitude on the inflammatory profile and carotid intima-media thickness (cIMT) in obese adolescents engaged in interdisciplinary therapy. DESIGN AND PATIENTS: Seventy-seven postpubertal obese adolescents with a BMI greater than the 95th percentile (37·18 ± 5·14), of both genders and between the ages of 14 and 19 years (16·74 ± 1·59) were subjected to a 1-year period of interdisciplinary intervention (nutrition, psychology, physical exercise and clinical support). MEASUREMENTS: Blood samples were collected to analyse glucose, lipid and adipokine concentrations. Body composition, anthropometric profiles and cIMT were measured. The results are presented according to quartiles of weight loss: 1st (≤5·80 kg) = low; 2nd (5·80-10·90 kg) = low to moderate; 3rd (10·90-15·90 kg) = moderate; and 4th (>15·90 kg) = massive. RESULTS: Leptin, the leptin/adiponectin ratio and plasminogen activator inhibitor 1 (PAI-1) were decreased significantly in the low-to-moderate weight loss. The cIMT was reduced in the moderate weight loss. Moreover, adiponectin was increased only in the massive weight loss. Additionally, weight loss was an independent predictor of changes in leptin level, the adiponectin/leptin ratio (A/L ratio) and PAI-1 when the data were adjusted for age and gender. BMI changes were predictors of changes in leptin and PAI-1 levels. A/L ratio was associated with lean body mass (%), independent of gender and age. In addition, changes in A/L ratio were independent predictors of cIMT alterations. CONCLUSIONS: Interdisciplinary therapy may reduce cardiovascular risk factors among adolescents depending on their degree of weight loss (moderate to massive) and when correlated with their inflammatory profile, metabolic state and cIMT.
BACKGROUND: Obesity is a chronic disease defined by an excess amount of adipose tissue and presents a low-grade inflammatory state, increasing cardiovascular risk. OBJECTIVE: To assess the effect of weight loss magnitude on the inflammatory profile and carotid intima-media thickness (cIMT) in obese adolescents engaged in interdisciplinary therapy. DESIGN AND PATIENTS: Seventy-seven postpubertal obese adolescents with a BMI greater than the 95th percentile (37·18 ± 5·14), of both genders and between the ages of 14 and 19 years (16·74 ± 1·59) were subjected to a 1-year period of interdisciplinary intervention (nutrition, psychology, physical exercise and clinical support). MEASUREMENTS: Blood samples were collected to analyse glucose, lipid and adipokine concentrations. Body composition, anthropometric profiles and cIMT were measured. The results are presented according to quartiles of weight loss: 1st (≤5·80 kg) = low; 2nd (5·80-10·90 kg) = low to moderate; 3rd (10·90-15·90 kg) = moderate; and 4th (>15·90 kg) = massive. RESULTS:Leptin, the leptin/adiponectin ratio and plasminogen activator inhibitor 1 (PAI-1) were decreased significantly in the low-to-moderate weight loss. The cIMT was reduced in the moderate weight loss. Moreover, adiponectin was increased only in the massive weight loss. Additionally, weight loss was an independent predictor of changes in leptin level, the adiponectin/leptin ratio (A/L ratio) and PAI-1 when the data were adjusted for age and gender. BMI changes were predictors of changes in leptin and PAI-1 levels. A/L ratio was associated with lean body mass (%), independent of gender and age. In addition, changes in A/L ratio were independent predictors of cIMT alterations. CONCLUSIONS: Interdisciplinary therapy may reduce cardiovascular risk factors among adolescents depending on their degree of weight loss (moderate to massive) and when correlated with their inflammatory profile, metabolic state and cIMT.
Authors: G Lambert; Marcelo Miranda de Oliveira Lima; A C Felici; J C Pareja; A C J Vasques; F S Novaes; S Rodovalho; F F P Hirsch; J R Matos-Souza; Élinton A Chaim; B Geloneze Journal: Obes Surg Date: 2018-01 Impact factor: 4.129
Authors: Bárbara Dal Molin Netto; Solange Cravo Bettini; Ana Paula Grotti Clemente; Joana Pereira de Carvalho Ferreira; Katia Boritza; Sandy de Fátima Souza; Maria Emilia Von der Heyde; Carrie P Earthman; Ana R Dâmaso Journal: Obes Surg Date: 2015-06 Impact factor: 4.129
Authors: Raquel Munhoz da Silveira Campos; Ana Raimunda Dâmaso; Deborah Cristina Landi Masquio; Antonio Eduardo Aquino; Marcela Sene-Fiorese; Fernanda Oliveira Duarte; Lian Tock; Nivaldo Antonio Parizotto; Vanderlei Salvador Bagnato Journal: Lasers Med Sci Date: 2015-05-10 Impact factor: 3.161
Authors: Cynthia M Kroeger; Monica C Klempel; Surabhi Bhutani; John F Trepanowski; Christine C Tangney; Krista A Varady Journal: Nutr Metab (Lond) Date: 2012-10-31 Impact factor: 4.169
Authors: Débora Estadella; Claudia M da Penha Oller do Nascimento; Lila M Oyama; Eliane B Ribeiro; Ana R Dâmaso; Aline de Piano Journal: Mediators Inflamm Date: 2013-01-31 Impact factor: 4.711