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Literature DB >> 22807261

A metal-based inhibitor of tumor necrosis factor-α.

Chung-Hang Leung¹, Hai-Jing Zhong, Hui Yang, Zhen Cheng, Daniel Shiu-Hin Chan, Victor Pui-Yan Ma, Ruben Abagyan, Chun-Yuen Wong, Dik-Lung Ma.

Abstract

Staying in the pocket: A cyclometalated iridium(III) biquinoline complex targets the protein-protein interface (see picture; C yellow, N blue, Ir dark green) of the tumor necrosis factor-α (TNF-α) trimer. Molecular-modeling studies confirm the nature of this interaction. Both enantiomers of the iridium complex display comparable in vitro potency to the strongest small-molecule inhibitor of TNF-α.

Entities: Chemical Gene

Mesh：

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Year: 2012 PMID： 22807261 DOI： 10.1002/anie.201202937

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

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Cited

33 in total

1. Novel Quinoline-based Ir(III) Complexes Exhibit High Antitumor Activity in Vitro and in Vivo.

Authors: Yan Yang; Yi-Dong Bin; Qi-Pin Qin; Xu-Jian Luo; Bi-Qun Zou; Hua-Xin Zhang
Journal: ACS Med Chem Lett Date: 2019-11-06 Impact factor: 4.345

2. DNA Interaction, Photocleavage and Topoisomerase I Inhibition by Ru(II) Complex with a New Ligand Possessing Phenazine Unit.

Authors: Xue-Wen Liu; You-Ming Shen; Jun-Shi Shu; Yang Xiao; Song-Bai Zhang; Ji-Lin Lu
Journal: J Fluoresc Date: 2015-08-19 Impact factor: 2.217

3. Fullerenes and their derivatives as inhibitors of tumor necrosis factor-α with highly promoted affinities.

Authors: Gaoyin Wu; Xuejiao J Gao; Joonkyung Jang; Xingfa Gao
Journal: J Mol Model Date: 2016-06-18 Impact factor: 1.810

4. Aminoquinoline-Rhodium(II) Conjugates as Src-Family SH3 Ligands.

Authors: Samuel C Martin; Zachary T Ball
Journal: ACS Med Chem Lett Date: 2019-09-09 Impact factor: 4.345

5. Cyclometalated rhodium and iridium complexes with imidazole containing Schiff bases: Synthesis, structure and cellular imaging.

Authors: Soumik Mandal; Dipak K Poria; Dipravath K Seth; Partho Sarothi Ray; Parna Gupta
Journal: Polyhedron Date: 2014-02-10 Impact factor: 3.052

A metal-based inhibitor of tumor necrosis factor-α.

1. Novel Quinoline-based Ir(III) Complexes Exhibit High Antitumor Activity in Vitro and in Vivo.

2. DNA Interaction, Photocleavage and Topoisomerase I Inhibition by Ru(II) Complex with a New Ligand Possessing Phenazine Unit.

3. Fullerenes and their derivatives as inhibitors of tumor necrosis factor-α with highly promoted affinities.

4. Aminoquinoline-Rhodium(II) Conjugates as Src-Family SH3 Ligands.

5. Cyclometalated rhodium and iridium complexes with imidazole containing Schiff bases: Synthesis, structure and cellular imaging.

6. Iridium(III) Luminescent Probe for Detection of the Malarial Protein Biomarker Histidine Rich Protein-II.

7. Identification of an iridium(III) complex with anti-bacterial and anti-cancer activity.

8. SerpentinaDB: a database of plant-derived molecules of Rauvolfia serpentina.

Review 9. Computational Prediction of RNA-Binding Proteins and Binding Sites.

Review 10. Organoiridium complexes: anticancer agents and catalysts.