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Literature DB >> 22806944

Reversible covalent inhibition of a protein target.

Chang-Uk Lee¹, Tom N Grossmann.

Abstract

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Year: 2012 PMID： 22806944 DOI： 10.1002/anie.201203341

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

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14 in total

Review 1. Covalent Inhibition in Drug Discovery.

Authors: Avick Kumar Ghosh; Indranil Samanta; Anushree Mondal; Wenshe Ray Liu
Journal: ChemMedChem Date: 2019-03-26 Impact factor: 3.466

2. Inhibition of Mcl-1 through covalent modification of a noncatalytic lysine side chain.

Authors: Gizem Akçay; Matthew A Belmonte; Brian Aquila; Claudio Chuaqui; Alexander W Hird; Michelle L Lamb; Philip B Rawlins; Nancy Su; Sharon Tentarelli; Neil P Grimster; Qibin Su
Journal: Nat Chem Biol Date: 2016-09-05 Impact factor: 15.040

3. Monocarbonyl analogs of curcumin inhibit growth of antibiotic sensitive and resistant strains of Mycobacterium tuberculosis.

Authors: Patrick R Baldwin; Analise Z Reeves; Kimberly R Powell; Ruth J Napier; Alyson I Swimm; Aiming Sun; Kyle Giesler; Bettina Bommarius; Thomas M Shinnick; James P Snyder; Dennis C Liotta; Daniel Kalman
Journal: Eur J Med Chem Date: 2015-01-10 Impact factor: 6.514

Review 4. Recent applications of covalent chemistries in protein-protein interaction inhibitors.

Authors: Alexandria M Chan; Christopher C Goodis; Elie G Pommier; Steven Fletcher
Journal: RSC Med Chem Date: 2022-06-03

5. Reversible inhibitors of regulators of G-protein signaling identified in a high-throughput cell-based calcium signaling assay.

Authors: Andrew J Storaska; Jian P Mei; Meng Wu; Min Li; Susan M Wade; Levi L Blazer; Benita Sjögren; Corey R Hopkins; Craig W Lindsley; Zhihong Lin; Joseph J Babcock; Owen B McManus; Richard R Neubig
Journal: Cell Signal Date: 2013-09-14 Impact factor: 4.315

Reversible covalent inhibition of a protein target.

Review 1. Covalent Inhibition in Drug Discovery.

2. Inhibition of Mcl-1 through covalent modification of a noncatalytic lysine side chain.

3. Monocarbonyl analogs of curcumin inhibit growth of antibiotic sensitive and resistant strains of Mycobacterium tuberculosis.

Review 4. Recent applications of covalent chemistries in protein-protein interaction inhibitors.

5. Reversible inhibitors of regulators of G-protein signaling identified in a high-throughput cell-based calcium signaling assay.

6. Monocarbonyl curcumin analogues: heterocyclic pleiotropic kinase inhibitors that mediate anticancer properties.

7. Incorporation of metabolically stable ketones into a small molecule probe to increase potency and water solubility.

8. Design, Synthesis, and Biological Evaluation of Novel Allosteric Protein Disulfide Isomerase Inhibitors.

Review 9. 'Borono-lectin' based engineering as a versatile platform for biomedical applications.

10. Impact of the structures of macrocyclic Michael acceptors on covalent proteasome inhibition.