INTRODUCTION: Histological characteristics of age-related muscle wasting are type II muscle fiber atrophy, accumulation of oxidative stress-induced lipofuscin granules and decreased satellite cell numbers. There is increasing clinical evidence for a strong correlation between chronic systemic inflammation and age-related muscle wasting. The aim of this study was to determine the impact of chronic systemic inflammation on age-related histological muscle characteristics. METHODS: As a model for chronic systemic inflammation, we included 10 patients suffering from rheumatoid arthritis (RA) and 27 control patients suffering from osteoarthritis (OA). Biopsies were taken from the vastus medialis muscle. RESULTS: No significant differences were found in type II muscle fiber atrophy, lipofuscin accumulation, or satellite cell number in RA compared with OA patients. CONCLUSIONS: These results suggest there is no association between chronic systemic inflammation in RA and age-related muscle characteristics. Future research should focus on inflammation and satellite cell function.
INTRODUCTION: Histological characteristics of age-related muscle wasting are type II muscle fiber atrophy, accumulation of oxidative stress-induced lipofuscin granules and decreased satellite cell numbers. There is increasing clinical evidence for a strong correlation between chronic systemic inflammation and age-related muscle wasting. The aim of this study was to determine the impact of chronic systemic inflammation on age-related histological muscle characteristics. METHODS: As a model for chronic systemic inflammation, we included 10 patients suffering from rheumatoid arthritis (RA) and 27 control patients suffering from osteoarthritis (OA). Biopsies were taken from the vastus medialis muscle. RESULTS: No significant differences were found in type II muscle fiber atrophy, lipofuscin accumulation, or satellite cell number in RA compared with OA patients. CONCLUSIONS: These results suggest there is no association between chronic systemic inflammation in RA and age-related muscle characteristics. Future research should focus on inflammation and satellite cell function.
Authors: Sandro Manuel Mueller; David Aguayo; Daniel Aeberli; Esther Vögelin; Marco Toigo Journal: Arthritis Res Ther Date: 2018-03-22 Impact factor: 5.156
Authors: Jessamine Y J Liu; Esmee M Reijnierse; Jeanine M van Ancum; Sjors Verlaan; Carel G M Meskers; Andrea B Maier Journal: PLoS One Date: 2019-04-15 Impact factor: 3.240
Authors: Suey S Y Yeung; Esmee M Reijnierse; Vivien K Pham; Marijke C Trappenburg; Wen Kwang Lim; Carel G M Meskers; Andrea B Maier Journal: J Cachexia Sarcopenia Muscle Date: 2019-04-16 Impact factor: 12.910