Literature DB >> 22805911

Calcium channel auxiliary α2δ and β subunits: trafficking and one step beyond.

Annette C Dolphin1.   

Abstract

The voltage-gated calcium channel α(2)δ and β subunits are traditionally considered to be auxiliary subunits that enhance channel trafficking, increase the expression of functional calcium channels at the plasma membrane and influence the channels' biophysical properties. Accumulating evidence indicates that these subunits may also have roles in the nervous system that are not directly linked to calcium channel function. For example, β subunits may act as transcriptional regulators, and certain α(2)δ subunits may function in synaptogenesis. The aim of this Review is to examine both the classic and novel roles for these auxiliary subunits in voltage-gated calcium channel function and beyond.

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Year:  2012        PMID： 22805911     DOI： 10.1038/nrn3311

Source DB:  PubMed          Journal:  Nat Rev Neurosci        ISSN： 1471-003X            Impact factor:   34.870


  169 in total

1.  Signaling to the nucleus by an L-type calcium channel-calmodulin complex through the MAP kinase pathway.

Authors:  R E Dolmetsch; U Pajvani; K Fife; J M Spotts; M E Greenberg
Journal:  Science       Date:  2001-10-12       Impact factor: 47.728

2.  3D structure of the skeletal muscle dihydropyridine receptor.

Authors:  Ming-Chuan Wang; Giles Velarde; Robert C Ford; Nicholas S Berrow; Annette C Dolphin; Ashraf Kitmitto
Journal:  J Mol Biol       Date:  2002-10-11       Impact factor: 5.469

3.  Targeted disruption of the voltage-dependent calcium channel alpha2/delta-1-subunit.

Authors:  Geraldine A Fuller-Bicer; Gyula Varadi; Sheryl E Koch; Masakazu Ishii; Ilona Bodi; Nijiat Kadeer; James N Muth; Gabor Mikala; Natalia N Petrashevskaya; Michael A Jordan; Sui-Po Zhang; Ning Qin; Christopher M Flores; Idit Isaacsohn; Maria Varadi; Yasuo Mori; W Keith Jones; Arnold Schwartz
Journal:  Am J Physiol Heart Circ Physiol       Date:  2009-05-08       Impact factor: 4.733

4.  Potentiation by the beta subunit of the ratio of the ionic current to the charge movement in the cardiac calcium channel.

Authors:  A Neely; X Wei; R Olcese; L Birnbaumer; E Stefani
Journal:  Science       Date:  1993-10-22       Impact factor: 47.728

5.  Gabapentin inhibits high-threshold calcium channel currents in cultured rat dorsal root ganglion neurones.

Authors:  K G Sutton; D J Martin; R D Pinnock; K Lee; R H Scott
Journal:  Br J Pharmacol       Date:  2002-01       Impact factor: 8.739

6.  Functional properties of a new voltage-dependent calcium channel alpha(2)delta auxiliary subunit gene (CACNA2D2).

Authors:  B Gao; Y Sekido; A Maximov; M Saad; E Forgacs; F Latif; M H Wei; M Lerman; J H Lee; E Perez-Reyes; I Bezprozvanny; J D Minna
Journal:  J Biol Chem       Date:  2000-04-21       Impact factor: 5.157

7.  Pain perception in mice lacking the beta3 subunit of voltage-activated calcium channels.

Authors:  Manabu Murakami; Bernd Fleischmann; Carmen De Felipe; Marc Freichel; Claudia Trost; Andreas Ludwig; Ulrich Wissenbach; Herbert Schwegler; Franz Hofmann; Jürgen Hescheler; Veit Flockerzi; Adolfo Cavalié
Journal:  J Biol Chem       Date:  2002-08-02       Impact factor: 5.157

8.  RIM1 confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca2+ channels.

Authors:  Shigeki Kiyonaka; Minoru Wakamori; Takafumi Miki; Yoshitsugu Uriu; Mio Nonaka; Haruhiko Bito; Aaron M Beedle; Emiko Mori; Yuji Hara; Michel De Waard; Motoi Kanagawa; Makoto Itakura; Masami Takahashi; Kevin P Campbell; Yasuo Mori
Journal:  Nat Neurosci       Date:  2007-05-13       Impact factor: 24.884

9.  Beta-subunits promote the expression of Ca(V)2.2 channels by reducing their proteasomal degradation.

Authors:  Dominic Waithe; Laurent Ferron; Karen M Page; Kanchan Chaggar; Annette C Dolphin
Journal:  J Biol Chem       Date:  2011-01-13       Impact factor: 5.157

10.  Mechanism of auxiliary subunit modulation of neuronal alpha1E calcium channels.

Authors:  L P Jones; S K Wei; D T Yue
Journal:  J Gen Physiol       Date:  1998-08       Impact factor: 4.086
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  175 in total

1.  Finding Channels.

Authors:  William A Catterall
Journal:  J Biol Chem       Date:  2015-10-02       Impact factor: 5.157

2.  Alternative Splicing in Ca(V)2.2 Regulates Neuronal Trafficking via Adaptor Protein Complex-1 Adaptor Protein Motifs.

Authors:  Natsuko Macabuag; Annette C Dolphin
Journal:  J Neurosci       Date:  2015-10-28       Impact factor: 6.167

Review 3.  Emerging roles for α2δ subunits in calcium channel function and synaptic connectivity.

Authors:  William Christopher Risher; Cagla Eroglu
Journal:  Curr Opin Neurobiol       Date:  2020-06-07       Impact factor: 6.627

4.  Genomic analysis identifies candidate pathogenic variants in 9 of 18 patients with unexplained West syndrome.

Authors:  Naomi Hino-Fukuyo; Atsuo Kikuchi; Natsuko Arai-Ichinoi; Tetsuya Niihori; Ryo Sato; Tasuku Suzuki; Hiroki Kudo; Yuko Sato; Tojo Nakayama; Yosuke Kakisaka; Yuki Kubota; Tomoko Kobayashi; Ryo Funayama; Keiko Nakayama; Mitsugu Uematsu; Yoko Aoki; Kazuhiro Haginoya; Shigeo Kure
Journal:  Hum Genet       Date:  2015-04-16       Impact factor: 4.132

5.  Methamphetamine blunts Ca(2+) currents and excitatory synaptic transmission through D1/5 receptor-mediated mechanisms in the mouse medial prefrontal cortex.

Authors:  Betina González; Celeste Rivero-Echeto; Javier A Muñiz; Jean Lud Cadet; Edgar García-Rill; Francisco J Urbano; Verónica Bisagno
Journal:  Addict Biol       Date:  2015-04-14       Impact factor: 4.280

Review 6.  Regulation of voltage-gated calcium channels by proteolysis.

Authors:  Kathryn Abele; Jian Yang
Journal:  Sheng Li Xue Bao       Date:  2012-10-25

7.  The HOOK region of β subunits controls gating of voltage-gated Ca2+ channels by electrostatically interacting with plasma membrane.

Authors:  Cheon-Gyu Park; Byung-Chang Suh
Journal:  Channels (Austin)       Date:  2017-06-01       Impact factor: 2.581

8.  Systemic pregabalin attenuates facial hypersensitivity and noxious stimulus-evoked release of glutamate in medullary dorsal horn in a rodent model of trigeminal neuropathic pain.

Authors:  Naresh Kumar; Pavel S Cherkas; Vidya Varathan; Makiko Miyamoto; Chen Yu Chiang; Jonathan O Dostrovsky; Barry J Sessle; Terence J Coderre
Journal:  Neurochem Int       Date:  2013-02-26       Impact factor: 3.921

9.  The α2δ-1-NMDA receptor coupling is essential for corticostriatal long-term potentiation and is involved in learning and memory.

Authors:  Jing-Jing Zhou; De-Pei Li; Shao-Rui Chen; Yi Luo; Hui-Lin Pan
Journal:  J Biol Chem       Date:  2018-10-24       Impact factor: 5.157

10.  LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1) Regulates Smooth Muscle Contractility by Modulating Ca2+ Signaling and Expression of Cytoskeleton-Related Proteins.

Authors:  Dianaly T Au; Zhekang Ying; Erick O Hernández-Ochoa; William E Fondrie; Brian Hampton; Mary Migliorini; Rebeca Galisteo; Martin F Schneider; Alan Daugherty; Debra L Rateri; Dudley K Strickland; Selen C Muratoglu
Journal:  Arterioscler Thromb Vasc Biol       Date:  2018-11       Impact factor: 8.311
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