OBJECTIVE: To elaborate a nomogram based on markers of ovarian reserve for the calculation of the appropriate starting dose of follicle-stimulating hormone (FSH). DESIGN: Cohort study of infertile women. SETTING: In vitro fertilisation (IVF) unit, University Hospital of Modena, Italy. POPULATION: Women aged 18-40 years (n = 346) and undergoing their first IVF cycle. METHODS: Serum FSH and anti-Müllerian hormone (AMH) measurement. MAIN OUTCOME MEASURES: Development of a model for the prediction of ovarian response to FSH. RESULTS: A model based on age, AMH and FSH was able to accurately predict the ovarian sensitivity and accounted for 30% of the variability of ovarian response to FSH. An FSH dosage nomogram was constructed and overall it predicts a starting FSH dose <225 IU in 55.1 and 25.9% of women younger and older than 35 years, respectively. CONCLUSIONS: In the present study we clearly demonstrated that the daily FSH dose may be calculated on the basis of a woman's age and two markers of ovarian reserve, namely AMH and FSH, with the first two vari;s (age and AMH) being the most significant predictors. The nomogram we developed seems easily applicable for clinicians during their daily clinical practice.
OBJECTIVE: To elaborate a nomogram based on markers of ovarian reserve for the calculation of the appropriate starting dose of follicle-stimulating hormone (FSH). DESIGN: Cohort study of infertile women. SETTING: In vitro fertilisation (IVF) unit, University Hospital of Modena, Italy. POPULATION: Women aged 18-40 years (n = 346) and undergoing their first IVF cycle. METHODS: Serum FSH and anti-Müllerian hormone (AMH) measurement. MAIN OUTCOME MEASURES: Development of a model for the prediction of ovarian response to FSH. RESULTS: A model based on age, AMH and FSH was able to accurately predict the ovarian sensitivity and accounted for 30% of the variability of ovarian response to FSH. An FSH dosage nomogram was constructed and overall it predicts a starting FSH dose <225 IU in 55.1 and 25.9% of women younger and older than 35 years, respectively. CONCLUSIONS: In the present study we clearly demonstrated that the daily FSH dose may be calculated on the basis of a woman's age and two markers of ovarian reserve, namely AMH and FSH, with the first two vari;s (age and AMH) being the most significant predictors. The nomogram we developed seems easily applicable for clinicians during their daily clinical practice.
Authors: Human Fatemi; Wilma Bilger; Deborah Denis; Georg Griesinger; Antonio La Marca; Salvatore Longobardi; Mary Mahony; Xiaoyan Yin; Thomas D'Hooghe Journal: Reprod Biol Endocrinol Date: 2021-05-11 Impact factor: 5.211
Authors: Joao Batista A Oliveira; Ricardo L R Baruffi; Claudia G Petersen; Ana L Mauri; Adriana M Nascimento; Laura Vagnini; Juliana Ricci; Mario Cavagna; Jose G Franco Journal: Reprod Biol Endocrinol Date: 2012-11-21 Impact factor: 5.211
Authors: Sarah F Lensen; Jack Wilkinson; Jori A Leijdekkers; Antonio La Marca; Ben Willem J Mol; Jane Marjoribanks; Helen Torrance; Frank J Broekmans Journal: Cochrane Database Syst Rev Date: 2018-02-01
Authors: Raoul Orvieto; Christos A Venetis; Human M Fatemi; Thomas D'Hooghe; Robert Fischer; Yulia Koloda; Marcos Horton; Michael Grynberg; Salvatore Longobardi; Sandro C Esteves; Sesh K Sunkara; Yuan Li; Carlo Alviggi Journal: Front Endocrinol (Lausanne) Date: 2021-05-10 Impact factor: 5.555