BACKGROUND AND OBJECTIVE: Resin-based dental materials may intraorally release their chemical components and bisphenol A. The New England Children's Amalgam Trial found that children randomized to amalgam had better psychosocial outcomes than those assigned to composites for posterior tooth restorations. The objective of this study was to examine whether greater exposure to dental composites is associated with psychosocial problems in children. METHODS: Analysis of treatment-level data from the New England Children's Amalgam Trial, a 2-group randomized safety trial comparing amalgam with the treatment plan of bisphenol A-glycidyl methacrylate (bisGMA)-based composite and urethane dimethacrylate-based polyacid-modified composite (compomer), among 534 children aged 6 to 10 years at baseline. Psychosocial function at follow-up (n = 434) was measured by using the self-reported Behavior Assessment System for Children (BASC-SR) and parent-reported Child Behavior Checklist (CBCL). RESULTS:Children with higher cumulative exposure to bisGMA-based composite had poorer follow-up scores on 3 of 4 BASC-SR global scales: Emotional Symptoms (β = 0.8, SE = 0.3, P = .003), Clinical Maladjustment (β = 0.7, SE = 0.3, P = .02), and Personal Adjustment (β = -0.8, SE = 0.2, P = .002). Associations were stronger with posterior-occlusal (chewing) surfaces, where degradation of composite was more likely. For CBCL change, associations were not statistically significant. At-risk or clinically significant scores were more common among children with greater exposure for CBCL Total Problem Behaviors (16.3% vs 11.2%, P-trend = .01) and numerous BASC-SR syndromes (eg, ≥ 13 vs 0 surface-years, Interpersonal Relations 13.7% vs 4.8%, P-trend = .01). No associations were found with compomer, nor with amalgam exposure levels among children randomized to amalgam. CONCLUSIONS: Greater exposure to bisGMA-based dental composite restorations was associated with impaired psychosocial function in children, whereas no adverse psychosocial outcomes were observed with greater urethane dimethacrylate-based compomer or amalgam treatment levels.
RCT Entities:
BACKGROUND AND OBJECTIVE: Resin-based dental materials may intraorally release their chemical components and bisphenol A. The New England Children's Amalgam Trial found that children randomized to amalgam had better psychosocial outcomes than those assigned to composites for posterior tooth restorations. The objective of this study was to examine whether greater exposure to dental composites is associated with psychosocial problems in children. METHODS: Analysis of treatment-level data from the New England Children's Amalgam Trial, a 2-group randomized safety trial comparing amalgam with the treatment plan of bisphenol A-glycidyl methacrylate (bisGMA)-based composite and urethane dimethacrylate-based polyacid-modified composite (compomer), among 534 children aged 6 to 10 years at baseline. Psychosocial function at follow-up (n = 434) was measured by using the self-reported Behavior Assessment System for Children (BASC-SR) and parent-reported Child Behavior Checklist (CBCL). RESULTS:Children with higher cumulative exposure to bisGMA-based composite had poorer follow-up scores on 3 of 4 BASC-SR global scales: Emotional Symptoms (β = 0.8, SE = 0.3, P = .003), Clinical Maladjustment (β = 0.7, SE = 0.3, P = .02), and Personal Adjustment (β = -0.8, SE = 0.2, P = .002). Associations were stronger with posterior-occlusal (chewing) surfaces, where degradation of composite was more likely. For CBCL change, associations were not statistically significant. At-risk or clinically significant scores were more common among children with greater exposure for CBCL Total Problem Behaviors (16.3% vs 11.2%, P-trend = .01) and numerous BASC-SR syndromes (eg, ≥ 13 vs 0 surface-years, Interpersonal Relations 13.7% vs 4.8%, P-trend = .01). No associations were found with compomer, nor with amalgam exposure levels among children randomized to amalgam. CONCLUSIONS: Greater exposure to bisGMA-based dental composite restorations was associated with impaired psychosocial function in children, whereas no adverse psychosocial outcomes were observed with greater urethane dimethacrylate-based compomer or amalgam treatment levels.
Authors: Abby F Fleisch; Perry E Sheffield; Courtney Chinn; Burton L Edelstein; Philip J Landrigan Journal: Pediatrics Date: 2010-09-06 Impact factor: 7.124
Authors: H Allison Bender; Dominick Auciello; Chris E Morrison; William S MacAllister; Charles M Zaroff Journal: Epilepsy Behav Date: 2008-04-29 Impact factor: 2.937
Authors: Iain A Lang; Tamara S Galloway; Alan Scarlett; William E Henley; Michael Depledge; Robert B Wallace; David Melzer Journal: JAMA Date: 2008-09-16 Impact factor: 56.272
Authors: Catherine A Richter; Linda S Birnbaum; Francesca Farabollini; Retha R Newbold; Beverly S Rubin; Chris E Talsness; John G Vandenbergh; Debby R Walser-Kuntz; Frederick S vom Saal Journal: Reprod Toxicol Date: 2007-06-26 Impact factor: 3.143
Authors: Joe M Braun; Kimberly Yolton; Kim N Dietrich; Richard Hornung; Xiaoyun Ye; Antonia M Calafat; Bruce P Lanphear Journal: Environ Health Perspect Date: 2009-10-06 Impact factor: 9.031
Authors: Nancy Nairi Maserejian; Felicia L Trachtenberg; Susan F Assmann; Lars Barregard Journal: Environ Health Perspect Date: 2008-02 Impact factor: 9.031
Authors: Emily L Roen; Ya Wang; Antonia M Calafat; Shuang Wang; Amy Margolis; Julie Herbstman; Lori A Hoepner; Virginia Rauh; Frederica P Perera Journal: Environ Res Date: 2015-02-24 Impact factor: 6.498
Authors: Frederica Perera; Emily L Roen Nolte; Ya Wang; Amy E Margolis; Antonia M Calafat; Shuang Wang; Wanda Garcia; Lori A Hoepner; Bradley S Peterson; Virginia Rauh; Julie Herbstman Journal: Environ Res Date: 2016-08-03 Impact factor: 6.498
Authors: Nancy N Maserejian; Peter Shrader; Felicia L Trachtenberg; Russ Hauser; David C Bellinger; Mary Tavares Journal: Pediatr Dent Date: 2014 Jan-Feb Impact factor: 1.874
Authors: Nancy N Maserejian; Felicia L Trachtenberg; Russ Hauser; Sonja McKinlay; Peter Shrader; David C Bellinger Journal: Neurotoxicology Date: 2012-08-14 Impact factor: 4.294
Authors: Kim G Harley; Robert B Gunier; Katherine Kogut; Caroline Johnson; Asa Bradman; Antonia M Calafat; Brenda Eskenazi Journal: Environ Res Date: 2013-07-17 Impact factor: 6.498