BACKGROUND: Polyomavirus reactivation can cause significant morbidity in solid organ transplant recipients, particularly BK virus (BKV) in kidney transplant patients. Less is known about dynamics of John Cunningham virus (JCV) in nonkidney organ transplant patients. METHODS: We examined the frequency of urinary shedding of polyomaviruses BKV and JCV and their relationship to creatinine clearance (CrCl) in a longitudinal study of 41 kidney and 33 liver transplant recipients. RESULTS: Any polyomavirus urinary shedding was more frequent in liver than kidney recipients (64% vs 39%; P= .03). JCV was excreted more frequently by liver than kidney recipients (71% vs 38%), whereas BKV was shed more often by kidney than liver patients (69% vs 52%). Mean JCV loads were significantly higher than those of BKV in both patient groups (P< .0001). Lower mean CrCl values were significantly associated with JCV shedding in both kidney and liver recipients (P< .001). CONCLUSIONS: These findings suggest that BKV and JCV display different patterns of reactivation and shedding in kidney and liver transplant patients and that JCV may have a role in renal dysfunction in some solid organ transplant recipients.
BACKGROUND:Polyomavirus reactivation can cause significant morbidity in solid organ transplant recipients, particularly BK virus (BKV) in kidney transplant patients. Less is known about dynamics of John Cunningham virus (JCV) in nonkidney organ transplant patients. METHODS: We examined the frequency of urinary shedding of polyomavirusesBKV and JCV and their relationship to creatinine clearance (CrCl) in a longitudinal study of 41 kidney and 33 liver transplant recipients. RESULTS: Any polyomavirus urinary shedding was more frequent in liver than kidney recipients (64% vs 39%; P= .03). JCV was excreted more frequently by liver than kidney recipients (71% vs 38%), whereas BKV was shed more often by kidney than liver patients (69% vs 52%). Mean JCV loads were significantly higher than those of BKV in both patient groups (P< .0001). Lower mean CrCl values were significantly associated with JCV shedding in both kidney and liver recipients (P< .001). CONCLUSIONS: These findings suggest that BKV and JCV display different patterns of reactivation and shedding in kidney and liver transplant patients and that JCV may have a role in renal dysfunction in some solid organ transplant recipients.
Authors: Xavier Verhelst; Geert Vanhooren; Ludo Vanopdenbosch; Jan Casselman; Wim Laleman; Jacques Pirenne; Frederik Nevens; Hans Orlent Journal: Transpl Int Date: 2010-12-07 Impact factor: 3.782
Authors: Lora D Thomas; Aaron P Milstone; Regis A Vilchez; Preeti Zanwar; Janet S Butel; J Stephen Dummer Journal: Transplantation Date: 2009-08-15 Impact factor: 4.939
Authors: Leandro Magalhães de Souza; Flávia Savassi-Ribas; Stephanie G S de Almeida; Rubens Nei N da Silva; Camila F Baez; Mariano Gustavo Zalis; Maria Angelica Arpon Marandino Guimarães; Rafael Brandão Varella Journal: Rev Inst Med Trop Sao Paulo Date: 2018-09-13 Impact factor: 1.846
Authors: Peter W Schreiber; Verena Kufner; Kerstin Hübel; Stefan Schmutz; Osvaldo Zagordi; Amandeep Kaur; Cornelia Bayard; Michael Greiner; Andrea Zbinden; Riccarda Capaul; Jürg Böni; Hans H Hirsch; Thomas F Mueller; Nicolas J Mueller; Alexandra Trkola; Michael Huber Journal: Clin Infect Dis Date: 2019-08-30 Impact factor: 9.079
Authors: Darlene Vigil; Nikifor K Konstantinov; Marc Barry; Antonia M Harford; Karen S Servilla; Young Ho Kim; Yijuan Sun; Kavitha Ganta; Antonios H Tzamaloukas Journal: World J Transplant Date: 2016-09-24