Literature DB >> 22802416

Blocking Fcα receptor I on granulocytes prevents tissue damage induced by IgA autoantibodies.

Lydia P van der Steen1, Jantine E Bakema, Alina Sesarman, Florina Florea, Cornelis W Tuk, Gudula Kirtschig, J Joris Hage, Cassian Sitaru, Marjolein van Egmond.   

Abstract

IgA represents the most prominent Ab class at mucosal surfaces and the second most prevalent Ab in human blood after IgG. We recently demonstrated that cross-linking of the granulocyte IgA FcR (FcαRI) by IgA induces a chemotactic-driven positive-feedback migration loop, hereby amplifying recruitment of granulocytes to IgA deposits. Therefore, we postulated that aberrant IgA-Ag complexes, which can be found in tissues in IgA-mediated diseases, are responsible for tissue damage by inducing continuous granulocyte migration and activation. Using an IgA-dependent skin-blistering disease as a model system, we demonstrated colocalization of FcαRI-positive granulocyte infiltrates with IgA in cryosections of lesional skin of patients suffering from this disease. Furthermore, we showed granulocyte migration to IgA deposits injected in human skin explants and in murine skin of FcαRI transgenic mice in vivo. Importantly, ex vivo migration and tissue damage were inhibited by blocking FcαRI, indicating that these events are dependent on the interaction of IgA autoantibodies with FcαRI. Thus, interrupting the granulocyte migration loop by blocking FcαRI reduces tissue damage in diseases with aberrant IgA-immune complexes. As such, our results may lead to development of new therapies for IgA-mediated chronic inflammatory diseases, hereby decreasing severe morbidity and improving quality of life for these patients.

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Year:  2012        PMID: 22802416     DOI: 10.4049/jimmunol.1101763

Source DB:  PubMed          Journal:  J Immunol        ISSN: 0022-1767            Impact factor:   5.422


  17 in total

1.  Targeted IgA Fc receptor I (FcαRI) therapy in the early intervention and treatment of pristane-induced lupus nephritis in mice.

Authors:  C Liu; Y Kanamaru; T Watanabe; N Tada; S Horikoshi; Y Suzuki; Z Liu; Y Tomino
Journal:  Clin Exp Immunol       Date:  2015-07-02       Impact factor: 4.330

Review 2.  Immunotherapy in allergy and cellular tests: state of art.

Authors:  Salvatore Chirumbolo
Journal:  Hum Vaccin Immunother       Date:  2014-05-02       Impact factor: 3.452

3.  Autoantibodies to Multiple Epitopes on the Non-Collagenous-1 Domain of Type VII Collagen Induce Blisters.

Authors:  Artem Vorobyev; Hideyuki Ujiie; Andreas Recke; Jacqueline J A Buijsrogge; Marcel F Jonkman; Hendri H Pas; Hiroaki Iwata; Takashi Hashimoto; Soo-Chan Kim; Jong Hoon Kim; Richard Groves; Unni Samavedam; Yask Gupta; Enno Schmidt; Detlef Zillikens; Hiroshi Shimizu; Ralf J Ludwig
Journal:  J Invest Dermatol       Date:  2015-02-17       Impact factor: 8.551

Review 4.  Neutrophil cell surface receptors and their intracellular signal transduction pathways.

Authors:  Krisztina Futosi; Szabina Fodor; Attila Mócsai
Journal:  Int Immunopharmacol       Date:  2013-08-30       Impact factor: 4.932

5.  Mediators of mast cells in bullous pemphigoid and dermatitis herpetiformis.

Authors:  Agnieszka Zebrowska; Malgorzata Wagrowska-Danilewicz; Marian Danilewicz; Olga Stasikowska-Kanicka; Lilianna Kulczycka-Siennicka; Anna Wozniacka; Elzbieta Waszczykowska
Journal:  Mediators Inflamm       Date:  2014-10-21       Impact factor: 4.711

6.  Whole-Genome Expression Profiling in Skin Reveals SYK As a Key Regulator of Inflammation in Experimental Epidermolysis Bullosa Acquisita.

Authors:  Unni K Samavedam; Nina Mitschker; Anika Kasprick; Katja Bieber; Enno Schmidt; Tamás Laskay; Andreas Recke; S Goletz; Gestur Vidarsson; Franziska S Schulze; Mikko Armbrust; Katharina Schulze Dieckhoff; Hendri H Pas; Marcel F Jonkman; Kathrin Kalies; Detlef Zillikens; Yask Gupta; Saleh M Ibrahim; Ralf J Ludwig
Journal:  Front Immunol       Date:  2018-02-15       Impact factor: 7.561

7.  Peptide mimetics of immunoglobulin A (IgA) and FcαRI block IgA-induced human neutrophil activation and migration.

Authors:  Marieke H Heineke; Lydia P E van der Steen; Rianne M Korthouwer; J Joris Hage; Johannes P M Langedijk; Joris J Benschop; Jantine E Bakema; Jerry W Slootstra; Marjolein van Egmond
Journal:  Eur J Immunol       Date:  2017-09-06       Impact factor: 5.532

Review 8.  Molecular diagnosis in autoimmune skin blistering conditions.

Authors:  J V Otten; T Hashimoto; M Hertl; A S Payne; C Sitaru
Journal:  Curr Mol Med       Date:  2014-01       Impact factor: 2.222

Review 9.  Anti-Citrullinated Protein Antibodies in Patients with Rheumatoid Arthritis: Biological Effects and Mechanisms of Immunopathogenesis.

Authors:  Chao-Yi Wu; Huang-Yu Yang; Jenn-Haung Lai
Journal:  Int J Mol Sci       Date:  2020-06-04       Impact factor: 5.923

Review 10.  Antigen recognition in the pathogenesis of immunoglobulin A-related autoimmune bullous diseases.

Authors:  Zhiliang Li; Ke Jing; Suo Li; Suying Feng
Journal:  Postepy Dermatol Alergol       Date:  2018-08-21       Impact factor: 1.837

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