Literature DB >> 22798912

7-{4-[(1,3-Benzodioxol-5-yl)meth-yl]piperazin-1-yl}-1-cyclo-propyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carb-oxy-lic acid.

Shuo Wang1, Guangzhi Shan, Huiyuan Guo, Mingliang Liu.   

Abstract

In the title structure, C(25)H(24)FN(3)O(5), a strong intra-molecular O-H⋯O hydrogen bond is present between the carb-oxy group at the 3-position and the carbonyl group at the 4-position. In the crystal, mol-ecules are held together by weak C-H⋯O, C-H⋯F and π-π [centroid-centroid distance 3.6080 (8) Å] inter-actions. The 1,4-dihydro-quinoline ring and cyclo-propyl group are not in the same plane, making an inter-planar angle of 57.52 (8)°.

Entities:  

Year:  2012        PMID: 22798912      PMCID: PMC3394047          DOI: 10.1107/S1600536812028711

Source DB:  PubMed          Journal:  Acta Crystallogr Sect E Struct Rep Online        ISSN: 1600-5368


  5 in total

1.  A short history of SHELX.

Authors:  George M Sheldrick
Journal:  Acta Crystallogr A       Date:  2007-12-21       Impact factor: 2.290

2.  Synthesis and in-vitro antimycobacterial activity of fluoroquinolone derivatives containing a coumarin moiety.

Authors:  Qiang Guo; Ming-Liang Liu; Lian-Shun Feng; Kai Lv; Yan Guan; Hui-Yuan Guo; Chun-Ling Xiao
Journal:  Arch Pharm (Weinheim)       Date:  2011-10-12       Impact factor: 3.751

Review 3.  Ciprofloxacin: review on developments in synthetic, analytical, and medicinal aspects.

Authors:  Prabodh Chander Sharma; Ankit Jain; Sandeep Jain; Rakesh Pahwa; Mohammad Shahar Yar
Journal:  J Enzyme Inhib Med Chem       Date:  2010-08       Impact factor: 5.051

4.  Synthesis and in vitro antimycobacterial activity of 8-OCH(3) ciprofloxacin methylene and ethylene isatin derivatives.

Authors:  Lian-Shun Feng; Ming-Liang Liu; Shu Zhang; Yun Chai; Bo Wang; Yi-Bin Zhang; Kai Lv; Yan Guan; Hui-Yuan Guo; Chun-Ling Xiao
Journal:  Eur J Med Chem       Date:  2010-11-24       Impact factor: 6.514

5.  Structure validation in chemical crystallography.

Authors:  Anthony L Spek
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2009-01-20
  5 in total

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