Literature DB >> 22798461

Fetal safety of calcium channel blockers.

Fatoumah Alabdulrazzaq, Gideon Koren.   

Abstract

QUESTION: Many of my pregnant or lactating patients are taking calcium channel blockers (CCBs) for hypertension. How safe is maternal use of CCBs for fetuses and nursing infants? ANSWER: Generally, CCBs have not been shown to increase teratogenic risk. Information regarding the safety of CCBs during lactation is limited, although they are not likely to pose a risk to the nursing infant.

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Year:  2012        PMID: 22798461      PMCID: PMC3395511     

Source DB:  PubMed          Journal:  Can Fam Physician        ISSN: 0008-350X            Impact factor:   3.275


  8 in total

Review 1.  Calcium channel antagonists and lactation: an update.

Authors:  M E Shannon; S E Malecha; A J Cha
Journal:  J Hum Lact       Date:  2000-02       Impact factor: 2.219

2.  The risk of limb deficiencies and other congenital abnormalities in children exposed in utero to calcium channel blockers.

Authors:  H T Sørensen; A E Czeizel; M Rockenbauer; F H Steffensen; J Olsen
Journal:  Acta Obstet Gynecol Scand       Date:  2001-05       Impact factor: 3.636

Review 3.  Use of antihypertensive drugs during pregnancy and lactation.

Authors:  Firas A Ghanem; Assad Movahed
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4.  American Academy of Pediatrics Committee on Drugs: The transfer of drugs and other chemicals into human milk.

Authors: 
Journal:  Pediatrics       Date:  1994-01       Impact factor: 7.124

5.  Risks of congenital malformations and perinatal events among infants exposed to calcium channel and beta-blockers during pregnancy.

Authors:  Robert L Davis; David Eastman; Heather McPhillips; Marsha A Raebel; Susan E Andrade; David Smith; Marianne Ulcickas Yood; Sascha Dublin; Richard Platt
Journal:  Pharmacoepidemiol Drug Saf       Date:  2010-11-15       Impact factor: 2.890

6.  Pharmacokinetics of verapamil in lactating rabbits. Prediction of verapamil distribution into rabbit milk.

Authors:  C Solans; J J Aramayona; M A Bregante; L J Fraile; S Rueda; M A Garcia
Journal:  Gen Pharmacol       Date:  2000-04

7.  The safety of calcium channel blockers in human pregnancy: a prospective, multicenter cohort study.

Authors:  L A Magee; B Schick; A E Donnenfeld; S R Sage; B Conover; L Cook; P R McElhatton; M A Schmidt; G Koren
Journal:  Am J Obstet Gynecol       Date:  1996-03       Impact factor: 8.661

8.  Maternal use of antihypertensive drugs in early pregnancy and delivery outcome, notably the presence of congenital heart defects in the infants.

Authors:  Roland Lennestål; Petra Otterblad Olausson; Bengt Källén
Journal:  Eur J Clin Pharmacol       Date:  2009-02-07       Impact factor: 2.953

  8 in total
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  2 in total

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