Literature DB >> 22798219

Rigorous quantitative sciences integration--the foundation of high-dimensional genomic research.

Yu Shyr1.   

Abstract

With the recent rapid increases in the high-dimensionality of genomic data generation comes an increased burden on the biostatisticians and bioinformaticians who process and analyze this data. Study designs must be adapted to the volume of data now available, eliminating designs that rely on fishing and taking advantage of the massive amounts of publically available genomic data through data-mining. Most importantly, it is no longer sufficient to have a single person handling the data analysis. To get the breadth of expertise needed to analyze high-dimensional data and to have the appropriate checks to eliminate the costly mistakes that are so easy to make when handling this volume of data, specialists from many different areas of quantitative sciences must be brought together to approach high-dimensional data analysis as an integrated team.

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Year:  2012        PMID: 22798219      PMCID: PMC3485411          DOI: 10.1007/s10585-012-9508-y

Source DB:  PubMed          Journal:  Clin Exp Metastasis        ISSN: 0262-0898            Impact factor:   5.150


  6 in total

1.  Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies.

Authors:  Brian D Lehmann; Joshua A Bauer; Xi Chen; Melinda E Sanders; A Bapsi Chakravarthy; Yu Shyr; Jennifer A Pietenpol
Journal:  J Clin Invest       Date:  2011-07       Impact factor: 14.808

2.  Genomic signatures to guide the use of chemotherapeutics.

Authors:  Anil Potti; Holly K Dressman; Andrea Bild; Richard F Riedel; Gina Chan; Robyn Sayer; Janiel Cragun; Hope Cottrill; Michael J Kelley; Rebecca Petersen; David Harpole; Jeffrey Marks; Andrew Berchuck; Geoffrey S Ginsburg; Phillip Febbo; Johnathan Lancaster; Joseph R Nevins
Journal:  Nat Med       Date:  2006-10-22       Impact factor: 53.440

3.  MALDI-MS derived prognostic protein markers for resected non-small cell lung cancer.

Authors:  Baogang J Xu; Adriana L Gonzalez; Takefumi Kikuchi; Kiyoshi Yanagisawa; Pierre P Massion; Huiyun Wu; Stephen E Mason; Sandy J Olson; Yu Shyr; David P Carbone; Richard M Caprioli
Journal:  Proteomics Clin Appl       Date:  2008-09-10       Impact factor: 3.494

4.  Proteomic patterns of tumour subsets in non-small-cell lung cancer.

Authors:  Kiyoshi Yanagisawa; Yu Shyr; Baogang J Xu; Pierre P Massion; Paul H Larsen; Bill C White; John R Roberts; Mary Edgerton; Adriana Gonzalez; Sorena Nadaf; Jason H Moore; Richard M Caprioli; David P Carbone
Journal:  Lancet       Date:  2003-08-09       Impact factor: 79.321

5.  Experimentally derived metastasis gene expression profile predicts recurrence and death in patients with colon cancer.

Authors:  J Joshua Smith; Natasha G Deane; Fei Wu; Nipun B Merchant; Bing Zhang; Aixiang Jiang; Pengcheng Lu; J Chad Johnson; Carl Schmidt; Christina E Bailey; Steven Eschrich; Christian Kis; Shawn Levy; M Kay Washington; Martin J Heslin; Robert J Coffey; Timothy J Yeatman; Yu Shyr; R Daniel Beauchamp
Journal:  Gastroenterology       Date:  2009-11-13       Impact factor: 22.682

6.  A training-testing approach to the molecular classification of resected non-small cell lung cancer.

Authors:  Noboru Yamagata; Yu Shyr; Kiyoshi Yanagisawa; Mary Edgerton; Thao P Dang; Adriana Gonzalez; Sorena Nadaf; Paul Larsen; John R Roberts; Jonathan C Nesbitt; Roy Jensen; Shawn Levy; Jason H Moore; John D Minna; David P Carbone
Journal:  Clin Cancer Res       Date:  2003-10-15       Impact factor: 12.531

  6 in total

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