Literature DB >> 22798167

Plasma polypyrrole implants recover motor function in rats after spinal cord transection.

Guillermo J Cruz1, Rodrigo Mondragón-Lozano, Araceli Diaz-Ruiz, Joaquín Manjarrez, Roberto Olayo, Hermelinda Salgado-Ceballos, Maria-Guadalupe Olayo, Juan Morales, Laura Alvarez-Mejía, Axayacatl Morales, Marisela Méndez-Armenta, Noel Plascencia, Maria del Carmen Fernandez, Camilo Ríos.   

Abstract

We studied the use of three biocompatible materials obtained by plasma polymerization of pyrrole (PPy), pyrrole doped with iodine (PPy/I) and a copolymer formed with pyrrole and polyethylene glycol (PPy/PEG), implanted, separately, after a complete spinal cord transection in rats. Motor function assessed with the BBB scale and somatosensory evoked potentials (SEPs) in the implanted rats were studied. Results showed that the highest motor recovery was obtained in rats with PPy/I implants. They also showed a significant reduction in the latency of SEPs. Histological analyses showed no signs of implant rejection; on the contrary, implants based on PPy improved the SEPs conduction and motor function after lesion.

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Year:  2012        PMID： 22798167     DOI： 10.1007/s10856-012-4715-2

Source DB:  PubMed          Journal:  J Mater Sci Mater Med        ISSN： 0957-4530            Impact factor:   3.896


  22 in total

1.  Prevention of spinal cord injury with time-frequency analysis of evoked potentials: an experimental study.

Authors:  Y Hu; K D Luk; W W Lu; A Holmes; J C Leong
Journal:  J Neurol Neurosurg Psychiatry       Date:  2001-12       Impact factor: 10.154

2.  Novel degradable co-polymers of polypyrrole support cell proliferation and enhance neurite out-growth with electrical stimulation.

Authors:  Hymavathi Durgam; Shawn Sapp; Curt Deister; Zin Khaing; Emily Chang; Silvia Luebben; Christine E Schmidt
Journal:  J Biomater Sci Polym Ed       Date:  2010-06-08       Impact factor: 3.517

Review 3.  Biopolymers and biodegradable smart implants for tissue regeneration after spinal cord injury.

Authors:  Liudmila N Novikova; Lev N Novikov; Jan-Olof Kellerth
Journal:  Curr Opin Neurol       Date:  2003-12       Impact factor: 5.710

4.  Reducing inflammation decreases secondary degeneration and functional deficit after spinal cord injury.

Authors:  Rafael Gonzalez; Janette Glaser; Michael T Liu; Thomas E Lane; Hans S Keirstead
Journal:  Exp Neurol       Date:  2003-11       Impact factor: 5.330

5.  Spontaneous long-term remyelination after traumatic spinal cord injury in rats.

Authors:  H Salgado-Ceballos; G Guizar-Sahagun; A Feria-Velasco; I Grijalva; L Espitia; A Ibarra; I Madrazo
Journal:  Brain Res       Date:  1998-01-26       Impact factor: 3.252

6.  Material properties and electrical stimulation regimens of polycaprolactone fumarate-polypyrrole scaffolds as potential conductive nerve conduits.

Authors:  Philipp Moroder; M Brett Runge; Huan Wang; Terry Ruesink; Lichun Lu; Robert J Spinner; Anthony J Windebank; Michael J Yaszemski
Journal:  Acta Biomater       Date:  2010-10-20       Impact factor: 8.947

7.  Perceived difficulty in dealing with consequences of spinal cord injury.

Authors:  E G Widerström-Noga; E Felipe-Cuervo; J G Broton; R C Duncan; R P Yezierski
Journal:  Arch Phys Med Rehabil       Date:  1999-05       Impact factor: 3.966

8.  Tissue spinal cord response in rats after implants of polypyrrole and polyethylene glycol obtained by plasma.

Authors:  Roberto Olayo; Camilo Ríos; Hermelinda Salgado-Ceballos; Guillermo Jesus Cruz; Juan Morales; Maria Guadalupe Olayo; Mireya Alcaraz-Zubeldia; Ana Laura Alvarez; Rodrigo Mondragon; Axayacatl Morales; Araceli Diaz-Ruiz
Journal:  J Mater Sci Mater Med       Date:  2007-08-01       Impact factor: 3.896

9.  Polypyrrole-coated electrospun PLGA nanofibers for neural tissue applications.

Authors:  Jae Y Lee; Chris A Bashur; Aaron S Goldstein; Christine E Schmidt
Journal:  Biomaterials       Date:  2009-06-07       Impact factor: 12.479

Review 10.  CNS injury, glial scars, and inflammation: Inhibitory extracellular matrices and regeneration failure.

Authors:  Michael T Fitch; Jerry Silver
Journal:  Exp Neurol       Date:  2007-05-31       Impact factor: 5.330
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  4 in total

1.  Effect of the combined treatment of albumin with plasma synthesised pyrrole polymers on motor recovery after traumatic spinal cord injury in rats.

Authors:  Omar Fabela-Sánchez; Hermelinda Salgado-Ceballos; Luis Medina-Torres; Laura Álvarez-Mejía; Stephany Sánchez-Torres; Rodrigo Mondragón-Lozano; Axayácatl Morales-Guadarrama; Araceli Díaz-Ruiz; María-Guadalupe Olayo; Guillermo J Cruz; Juan Morales; Camilo Ríos; Roberto Olayo
Journal:  J Mater Sci Mater Med       Date:  2017-12-28       Impact factor: 3.896

2.  Functional recovery in spinal cord injured rats using polypyrrole/iodine implants and treadmill training.

Authors:  Laura Alvarez-Mejia; Juan Morales; Guillermo J Cruz; María-Guadalupe Olayo; Roberto Olayo; Araceli Díaz-Ruíz; Camilo Ríos; Rodrigo Mondragón-Lozano; Stephanie Sánchez-Torres; Axayacatl Morales-Guadarrama; Omar Fabela-Sánchez; Hermelinda Salgado-Ceballos
Journal:  J Mater Sci Mater Med       Date:  2015-07-14       Impact factor: 3.896

Review 3.  Exercise Training Promotes Functional Recovery after Spinal Cord Injury.

Authors:  Juanjuan Fu; Hongxing Wang; Lingxiao Deng; Jianan Li
Journal:  Neural Plast       Date:  2016-12-06       Impact factor: 3.599

4.  Electrophysiological Recordings from Embryonic Mouse Motoneurons Cultured on Electrospun Poly-Lactic Acid (PLA) and Polypyrrole-Coated PLA Scaffolds.

Authors:  Esmeralda Zuñiga; Odin Ramírez; Carlos Martínez
Journal:  Iran Biomed J       Date:  2022-05-01
  4 in total

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