OBJECTIVES: To establish the undisputed the value of washout rate for adrenal adenoma using delayed enhanced CT, we evaluated diagnostic performance of cut-off value and delayed time of washout rate by final pathologic diagnosis in a multicenter study. METHODS: We reviewed the pathologic and clinical records of 244 patients underwent adrenalectomies at 5 university hospitals between 2005 and 2009. We calculated the mean Housfield units (HU) of adrenal lesion at non-enhancing CT, and early and delayed enhanced CT using the region of interest. We used ROC curves to determine the specificity and sensitivity of non-enhanced CT scans and the washout rate according to the various cut-off for adrenal adenomas. RESULTS: We divided the patients into adrenal adenoma group (n = 138) and non-adrenal adenoma group (n = 106) based on final pathologic report. Using the unenhanced images with a threshold of 10 HU, the sensitivity was 45.7 %, and the specificity was 97.1 %. Using the 15-min-washout rate with a threshold of 55 %, the sensitivity was 93.9 %, and the specificity was 95.8 %. CONCLUSIONS: Regardless of various CT machines and protocols, a washout rate of 15-min-delayed CT was most useful in the diagnosis of adrenal adenomas due to the early inflow and outflow of contrast media in the tissues of adrenal adenomas.
OBJECTIVES: To establish the undisputed the value of washout rate for adrenal adenoma using delayed enhanced CT, we evaluated diagnostic performance of cut-off value and delayed time of washout rate by final pathologic diagnosis in a multicenter study. METHODS: We reviewed the pathologic and clinical records of 244 patients underwent adrenalectomies at 5 university hospitals between 2005 and 2009. We calculated the mean Housfield units (HU) of adrenal lesion at non-enhancing CT, and early and delayed enhanced CT using the region of interest. We used ROC curves to determine the specificity and sensitivity of non-enhanced CT scans and the washout rate according to the various cut-off for adrenal adenomas. RESULTS: We divided the patients into adrenal adenoma group (n = 138) and non-adrenal adenoma group (n = 106) based on final pathologic report. Using the unenhanced images with a threshold of 10 HU, the sensitivity was 45.7 %, and the specificity was 97.1 %. Using the 15-min-washout rate with a threshold of 55 %, the sensitivity was 93.9 %, and the specificity was 95.8 %. CONCLUSIONS: Regardless of various CT machines and protocols, a washout rate of 15-min-delayed CT was most useful in the diagnosis of adrenal adenomas due to the early inflow and outflow of contrast media in the tissues of adrenal adenomas.
Authors: Minal J Sangwaiya; Giles W L Boland; Carmel G Cronin; Michael A Blake; Elkan F Halpern; Peter F Hahn Journal: Radiology Date: 2010-08 Impact factor: 11.105
Authors: Dieter H Szolar; Melvyn Korobkin; Pia Reittner; Andrea Berghold; Thomas Bauernhofer; Harald Trummer; Helmut Schoellnast; Klaus W Preidler; Hellmuth Samonigg Journal: Radiology Date: 2005-02 Impact factor: 11.105
Authors: Melvin M Grumbach; Beverly M K Biller; Glenn D Braunstein; Karen K Campbell; J Aidan Carney; Paul A Godley; Emily L Harris; Joseph K T Lee; Yolanda C Oertel; Mitchell C Posner; Janet A Schlechte; H Samuel Wieand Journal: Ann Intern Med Date: 2003-03-04 Impact factor: 25.391
Authors: Chaan S Ng; Emre Altinmakas; Wei Wei; Payel Ghosh; Xiao Li; Elizabeth G Grubbs; Nancy D Perrier; Jeffrey E Lee; Victor G Prieto; Brian P Hobbs Journal: AJR Am J Roentgenol Date: 2018-06-27 Impact factor: 3.959
Authors: Lucinda M Gruber; Veljko Strajina; Irina Bancos; M Hassan Murad; Benzon M Dy; William F Young; David R Farley; Melanie L Lyden; Geoffrey B Thompson; Travis J McKenzie Journal: Gland Surg Date: 2020-04
Authors: Joo Hyun Jun; Hyun Joo Ahn; Sangmin M Lee; Jie Ae Kim; Byung Kwan Park; Jee Soo Kim; Jung Han Kim Journal: Medicine (Baltimore) Date: 2015-11 Impact factor: 1.817