PURPOSE: To investigate the role of placental abnormalities in complicated and uncomplicated pregnancies in obese women. METHODS: Placentas from patients with complicated or uncomplicated pregnancies and a pregravid body mass index (BMI) of ≥30 kg/m2 were analyzed histopathologically for lesions consistent with maternal and fetal circulation abnormalities and inflammatory lesions related to the maternal or fetal response. Findings were compared with a normal-weight control group matched by mode of delivery and presence/type of pregnancy complications. RESULTS: The obese group consisted of 28 women of whom 46% had a complicated pregnancy. The obese group had a higher rate of maternal inflammatory lesions than the normal-weight control group (43 vs. 3.6%, p<0.001). There was no difference between the obese women with complicated and uncomplicated pregnancies in mean placental weight or lesions associated with fetal or maternal vascular supply. CONCLUSION: Placental inflammatory lesions may underlie the worse pregnancy course of obese women relative to normal-weight women.
PURPOSE: To investigate the role of placental abnormalities in complicated and uncomplicated pregnancies in obesewomen. METHODS: Placentas from patients with complicated or uncomplicated pregnancies and a pregravid body mass index (BMI) of ≥30 kg/m2 were analyzed histopathologically for lesions consistent with maternal and fetal circulation abnormalities and inflammatory lesions related to the maternal or fetal response. Findings were compared with a normal-weight control group matched by mode of delivery and presence/type of pregnancy complications. RESULTS: The obese group consisted of 28 women of whom 46% had a complicated pregnancy. The obese group had a higher rate of maternal inflammatory lesions than the normal-weight control group (43 vs. 3.6%, p<0.001). There was no difference between the obesewomen with complicated and uncomplicated pregnancies in mean placental weight or lesions associated with fetal or maternal vascular supply. CONCLUSION: Placental inflammatory lesions may underlie the worse pregnancy course of obesewomen relative to normal-weight women.
Authors: Elizabeth Ann L Enninga; Jin Sung Jang; Benjamin Hur; Erica L Johnson; Myra J Wick; Jaeyun Sung; Rana Chakraborty Journal: Am J Reprod Immunol Date: 2020-11-04 Impact factor: 3.886
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