Gregory J Nadolski1, Maxim Itkin2. 1. Department of Radiology, Section Interventional Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA. 2. Department of Radiology, Section Interventional Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA. Electronic address: itkinmax@gmail.com.
Abstract
BACKGROUND: Thoracic duct embolization (TDE) is an acceptable alternative procedure for treating traumatic chylothorax. The purpose of this study is to demonstrate efficacy of TDE in treating nontraumatic chylous effusions. METHODS: A retrospective review of 34 patients was conducted assessing technical and clinical success of TDE for nontraumatic chylous effusions. RESULTS: Thirty-four patients (mean age, 59 years; 27 female patients) with nontraumatic chylous effusions underwent TDE. Presentations included 21 unilateral chylothoraces (61.8%), nine bilateral chylothoraces (26.5%), two isolated chylopericardiums (5.9%), and two pleural effusions with chylopericardium (5.9%). TDE was technically successful in 24 of 34 patients (70.6%). The thoracic duct could not be catheterized in four of 34 (11.8%). Cisterna chyli was not visualized in six of 34 patients (17.6%), and, thus, TDE was not attempted. Follow-up was available for 32 patients. Four lymphangiographic patterns were observed: (1) normal thoracic duct in 17.6% of patients (six of 34), (2) occlusion of thoracic duct in 58.8% (20 of 34), (3) failure to opacify thoracic duct in 17.6% (six of 34), and (4) extravasation of chyle in 5.9% (two of 34). Clinical success varied with the lymphangiographic pattern. The clinical success rate was 16% (one of six) in cases of normal thoracic duct, 75% (15 of 20 patients) in occlusions of the thoracic duct, 16% (one of six) in cases of failure to opacify the thoracic duct, and 50% in two cases of chyle extravasation. Lymphangiography alone cured two patients (6.5%). CONCLUSION: TDE was most successful in cases of thoracic duct occlusion and extravasation. Lymphangiography is important for identifying the cause of chylous effusions and selecting patients who benefit most from TDE.
BACKGROUND: Thoracic duct embolization (TDE) is an acceptable alternative procedure for treating traumatic chylothorax. The purpose of this study is to demonstrate efficacy of TDE in treating nontraumatic chylous effusions. METHODS: A retrospective review of 34 patients was conducted assessing technical and clinical success of TDE for nontraumatic chylous effusions. RESULTS: Thirty-four patients (mean age, 59 years; 27 female patients) with nontraumatic chylous effusions underwent TDE. Presentations included 21 unilateral chylothoraces (61.8%), nine bilateral chylothoraces (26.5%), two isolated chylopericardiums (5.9%), and two pleural effusions with chylopericardium (5.9%). TDE was technically successful in 24 of 34 patients (70.6%). The thoracic duct could not be catheterized in four of 34 (11.8%). Cisterna chyli was not visualized in six of 34 patients (17.6%), and, thus, TDE was not attempted. Follow-up was available for 32 patients. Four lymphangiographic patterns were observed: (1) normal thoracic duct in 17.6% of patients (six of 34), (2) occlusion of thoracic duct in 58.8% (20 of 34), (3) failure to opacify thoracic duct in 17.6% (six of 34), and (4) extravasation of chyle in 5.9% (two of 34). Clinical success varied with the lymphangiographic pattern. The clinical success rate was 16% (one of six) in cases of normal thoracic duct, 75% (15 of 20 patients) in occlusions of the thoracic duct, 16% (one of six) in cases of failure to opacify the thoracic duct, and 50% in two cases of chyle extravasation. Lymphangiography alone cured two patients (6.5%). CONCLUSION: TDE was most successful in cases of thoracic duct occlusion and extravasation. Lymphangiography is important for identifying the cause of chylous effusions and selecting patients who benefit most from TDE.
Authors: Bill S Majdalany; Wael A Saad; Jeffrey Forris Beecham Chick; Minhaj S Khaja; Kyle J Cooper; Ravi N Srinivasa Journal: Pediatr Radiol Date: 2017-09-28
Authors: Laura A Vella; Marcus Buggert; Sasikanth Manne; Ramin S Herati; Ismail Sayin; Leticia Kuri-Cervantes; Irene Bukh Brody; Kaitlin C O'Boyle; Hagop Kaprielian; Josephine R Giles; Son Nguyen; Alexander Muselman; Jack P Antel; Amit Bar-Or; Matthew E Johnson; David H Canaday; Ali Naji; Vitaly V Ganusov; Terri M Laufer; Andrew D Wells; Yoav Dori; Maxim G Itkin; Michael R Betts; E John Wherry Journal: J Clin Invest Date: 2019-07-02 Impact factor: 14.808