Kai K Lee1, Alka Savani1, Sergio Matos2, David H Evans3, Ian D Pavord4, Surinder S Birring5. 1. Division of Asthma, Allergy, and Lung Biology, King's College London, London, England. 2. Institute of Electronics and Telematics Engineering, University of Aveiro, Aveiro, Portugal. 3. Department of Medical Physics, Leicester Royal Infirmary, Leicester, England. 4. Department of Respiratory Medicine, Institute for Lung Health, Glenfield Hospital, Leicester, England. 5. Division of Asthma, Allergy, and Lung Biology, King's College London, London, England. Electronic address: surinder.birring@nhs.net.
Abstract
BACKGROUND: The recent development of automated cough monitors has enabled objective assessment of cough frequency. A study was undertaken to determine whether short-duration recordings( < 6 h) accurately reflect 24-h cough frequency and to investigate their responsiveness. METHODS: One hundred adults with chronic cough underwent 24-h cough frequency monitoring with the Leicester Cough Monitor and completed cough visual analog scales (VASs) and the Leicester Cough Questionnaire (LCQ). Cough recordings were analyzed using customized software to derive cough frequencies from 1 to 6 h and 24-h recordings. Responsiveness was assessed with repeat assessments following therapeutic trials. RESULTS: The median (interquartile range) 24-h cough frequency was 11.5 (5.8-26.6) coughs/h. Four hours was considered the shortest recording duration that represented 24-h cough frequency( ρ= 0.9, P ≤ .001). Median 4-h cough frequency was 16.6 (7.3-36.8) coughs/h. Both 4-h and 24-h cough frequency correlated moderately with cough VAS ( ρ= 0.49, P ≤ .01 and ρ= 0.44, P ≤ .01)and LCQ ( ρ = - 0.48, P ≤ .01; ρ = - 0.50, P ≤ .01). Four-hour cough frequency was responsive to improvements in cough severity following trials of therapy. CONCLUSIONS: Four-hour cough frequency correlates highly with 24-h cough frequency recordings and relates equally well with subjective measures in chronic cough. Short-duration cough monitoring could be a practical tool to validate the presence of cough and assess response to trials of therapy in the clinic setting.
BACKGROUND: The recent development of automated cough monitors has enabled objective assessment of cough frequency. A study was undertaken to determine whether short-duration recordings( < 6 h) accurately reflect 24-h cough frequency and to investigate their responsiveness. METHODS: One hundred adults with chronic cough underwent 24-h cough frequency monitoring with the Leicester Cough Monitor and completed cough visual analog scales (VASs) and the Leicester Cough Questionnaire (LCQ). Cough recordings were analyzed using customized software to derive cough frequencies from 1 to 6 h and 24-h recordings. Responsiveness was assessed with repeat assessments following therapeutic trials. RESULTS: The median (interquartile range) 24-h cough frequency was 11.5 (5.8-26.6) coughs/h. Four hours was considered the shortest recording duration that represented 24-h cough frequency( ρ= 0.9, P ≤ .001). Median 4-h cough frequency was 16.6 (7.3-36.8) coughs/h. Both 4-h and 24-h cough frequency correlated moderately with cough VAS ( ρ= 0.49, P ≤ .01 and ρ= 0.44, P ≤ .01)and LCQ ( ρ = - 0.48, P ≤ .01; ρ = - 0.50, P ≤ .01). Four-hour cough frequency was responsive to improvements in cough severity following trials of therapy. CONCLUSIONS: Four-hour cough frequency correlates highly with 24-h cough frequency recordings and relates equally well with subjective measures in chronic cough. Short-duration cough monitoring could be a practical tool to validate the presence of cough and assess response to trials of therapy in the clinic setting.
Authors: Arietta Spinou; Kai K Lee; Aish Sinha; Caroline Elston; Michael R Loebinger; Robert Wilson; Kian Fan Chung; Nadia Yousaf; Ian D Pavord; Sergio Matos; Rachel Garrod; Surinder S Birring Journal: Lung Date: 2017-07-13 Impact factor: 2.584
Authors: Louis-Philippe Boulet; Remy R Coeytaux; Douglas C McCrory; Cynthia T French; Anne B Chang; Surinder S Birring; Jaclyn Smith; Rebecca L Diekemper; Bruce Rubin; Richard S Irwin Journal: Chest Date: 2015-03 Impact factor: 9.410
Authors: Alvaro Proaño; Marjory A Bravard; José W López; Gwenyth O Lee; David Bui; Sumona Datta; Germán Comina; Mirko Zimic; Jorge Coronel; Luz Caviedes; José L Cabrera; Antonio Salas; Eduardo Ticona; Nancy M Vu; Daniela E Kirwan; Maria-Cristina I Loader; Jon S Friedland; David A J Moore; Carlton A Evans; Brian H Tracey; Robert H Gilman Journal: Clin Infect Dis Date: 2017-05-01 Impact factor: 9.079
Authors: Kai K Lee; Sergio Matos; Katie Ward; Gerrard F Rafferty; John Moxham; David H Evans; Surinder S Birring Journal: BMJ Open Respir Res Date: 2017-05-12