Toll-like receptors in wound healing: location, accessibility, and timing.

Toll-like receptors (TLRs) are considered to be the first responders in the defense against invading pathogens. TLR engagement by ligands triggers inflammatory responses in injury and trauma, and thus can impair or contribute to the healing process, depending on TLRs' expression pattern, cellular localization, signaling, and deployment of inflammatory responses. Understanding these attributes could improve therapeutic strategies for treating chronic wounds.