PURPOSE: In patients at clinical high risk (CHR) of psychosis, transition to psychosis has been the focus of recent studies. Their broader outcome has received less attention. We studied psychosocial state and outcome in CHR patients. METHODS: In the European Prediction of Psychosis Study, 244 young help-seeking CHR patients were assessed with the Strauss and Carpenter Prognostic Scale (SCPS) at baseline, and 149 (61.1%) of them were assessed for the second time at the 18-month follow-up. The followed patients were classified into poor and good outcome groups. RESULTS: Female gender, ever-married/cohabitating relationship, and good working/studying situation were associated with good baseline SCPS scores. During follow-up, patients' SCPS scores improved significantly. Good follow-up SCPS scores were predicted by higher level of education, good working/studying status at baseline, and white ethnicity. One-third of the followed CHR patients had poor global outcome. Poor working/studying situation and lower level of education were associated with poor global outcome. Transition to psychosis was associated with baseline, but not with follow-up SCPS scores or with global outcome. CONCLUSION: The majority of CHR patients experience good short-term recovery, but one-third have poor psychosocial outcome. Good working situation is the major indicator of good outcome, while low level of education and non-white ethnicity seem to be associated with poor outcome. Transition to psychosis has little effect on psychosocial outcome in CHR patients. In treating CHR patients, clinicians should focus their attention on a broader outcome, and not only on preventing transition to psychosis.
PURPOSE: In patients at clinical high risk (CHR) of psychosis, transition to psychosis has been the focus of recent studies. Their broader outcome has received less attention. We studied psychosocial state and outcome in CHRpatients. METHODS: In the European Prediction of Psychosis Study, 244 young help-seeking CHRpatients were assessed with the Strauss and Carpenter Prognostic Scale (SCPS) at baseline, and 149 (61.1%) of them were assessed for the second time at the 18-month follow-up. The followed patients were classified into poor and good outcome groups. RESULTS: Female gender, ever-married/cohabitating relationship, and good working/studying situation were associated with good baseline SCPS scores. During follow-up, patients' SCPS scores improved significantly. Good follow-up SCPS scores were predicted by higher level of education, good working/studying status at baseline, and white ethnicity. One-third of the followed CHRpatients had poor global outcome. Poor working/studying situation and lower level of education were associated with poor global outcome. Transition to psychosis was associated with baseline, but not with follow-up SCPS scores or with global outcome. CONCLUSION: The majority of CHRpatients experience good short-term recovery, but one-third have poor psychosocial outcome. Good working situation is the major indicator of good outcome, while low level of education and non-white ethnicity seem to be associated with poor outcome. Transition to psychosis has little effect on psychosocial outcome in CHRpatients. In treating CHRpatients, clinicians should focus their attention on a broader outcome, and not only on preventing transition to psychosis.
Authors: Joachim Klosterkötter; Stephan Ruhrmann; Frauke Schultze-Lutter; Raimo K R Salokangas; Don Linszen; Max Birchwood; Georg Juckel; Anthony Morrison; José Luis Vázquèz-Barquero; Martin Hambrecht; Heinrich VON Reventlow Journal: World Psychiatry Date: 2005-10 Impact factor: 49.548
Authors: Hector W H Tsang; Ada Y Leung; Raymond C K Chung; Morris Bell; Wai-Ming Cheung Journal: Aust N Z J Psychiatry Date: 2010-06 Impact factor: 5.744
Authors: Danielle A Schlosser; Sarah Jacobson; Qiaolin Chen; Catherine A Sugar; Tara A Niendam; Gang Li; Carrie E Bearden; Tyrone D Cannon Journal: Schizophr Bull Date: 2011-08-08 Impact factor: 9.306
Authors: Eric C Meyer; Ricardo E Carrión; Barbara A Cornblatt; Jean Addington; Kristin S Cadenhead; Tyrone D Cannon; Thomas H McGlashan; Diana O Perkins; Ming T Tsuang; Elaine F Walker; Scott W Woods; Robert Heinssen; Larry J Seidman Journal: Schizophr Bull Date: 2014-02-18 Impact factor: 9.306
Authors: Nikolaos Koutsouleris; Lana Kambeitz-Ilankovic; Stephan Ruhrmann; Marlene Rosen; Anne Ruef; Dominic B Dwyer; Marco Paolini; Katharine Chisholm; Joseph Kambeitz; Theresa Haidl; André Schmidt; John Gillam; Frauke Schultze-Lutter; Peter Falkai; Maximilian Reiser; Anita Riecher-Rössler; Rachel Upthegrove; Jarmo Hietala; Raimo K R Salokangas; Christos Pantelis; Eva Meisenzahl; Stephen J Wood; Dirk Beque; Paolo Brambilla; Stefan Borgwardt Journal: JAMA Psychiatry Date: 2018-11-01 Impact factor: 21.596
Authors: Heike Anderson-Schmidt; Lothar Adler; Chadiga Aly; Ion-George Anghelescu; Michael Bauer; Jessica Baumgärtner; Joachim Becker; Roswitha Bianco; Thomas Becker; Cosima Bitter; Dominikus Bönsch; Karoline Buckow; Monika Budde; Martin Bührig; Jürgen Deckert; Sara Y Demiroglu; Detlef Dietrich; Michael Dümpelmann; Uta Engelhardt; Andreas J Fallgatter; Daniel Feldhaus; Christian Figge; Here Folkerts; Michael Franz; Katrin Gade; Wolfgang Gaebel; Hans-Jörgen Grabe; Oliver Gruber; Verena Gullatz; Linda Gusky; Urs Heilbronner; Krister Helbing; Ulrich Hegerl; Andreas Heinz; Tilman Hensch; Christoph Hiemke; Markus Jäger; Anke Jahn-Brodmann; Georg Juckel; Franz Kandulski; Wolfgang P Kaschka; Tilo Kircher; Manfred Koller; Carsten Konrad; Johannes Kornhuber; Marina Krause; Axel Krug; Mahsa Lee; Markus Leweke; Klaus Lieb; Mechthild Mammes; Andreas Meyer-Lindenberg; Moritz Mühlbacher; Matthias J Müller; Vanessa Nieratschker; Barbara Nierste; Jacqueline Ohle; Andrea Pfennig; Marlenna Pieper; Matthias Quade; Daniela Reich-Erkelenz; Andreas Reif; Markus Reitt; Bernd Reininghaus; Eva Z Reininghaus; Matthias Riemenschneider; Otto Rienhoff; Patrik Roser; Dan Rujescu; Rebecca Schennach; Harald Scherk; Max Schmauss; Frank Schneider; Alexandra Schosser; Björn H Schott; Sybille G Schwab; Jens Schwanke; Daniela Skrowny; Carsten Spitzer; Sebastian Stierl; Judith Stöckel; Susanne Stübner; Andreas Thiel; Hans-Peter Volz; Martin von Hagen; Henrik Walter; Stephanie H Witt; Thomas Wobrock; Jürgen Zielasek; Jörg Zimmermann; Antje Zitzelsberger; Wolfgang Maier; Peter G Falkai; Marcella Rietschel; Thomas G Schulze Journal: Eur Arch Psychiatry Clin Neurosci Date: 2013-04-03 Impact factor: 5.270
Authors: Renate L E P Reniers; Ashleigh Lin; Alison R Yung; Nikolaos Koutsouleris; Barnaby Nelson; Vanessa L Cropley; Dennis Velakoulis; Patrick D McGorry; Christos Pantelis; Stephen J Wood Journal: Schizophr Bull Date: 2017-03-01 Impact factor: 9.306
Authors: Raimo K R Salokangas; Tiina From; Tuula Ilonen; Sinikka Luutonen; Markus Heinimaa; Reetta-Liina Armio; Heikki Laurikainen; Maija Walta; Janina Paju; Anna Toivonen; Päivi Jalo; Lauri Tuominen; Jarmo Hietala Journal: BMC Psychiatry Date: 2021-12-02 Impact factor: 3.630