Literature DB >> 22797078

Ruthenium- and osmium-arene-based paullones bearing a TEMPO free-radical unit as potential anticancer drugs.

Vladimir B Arion1, Anatolie Dobrov, Simone Göschl, Michael A Jakupec, Bernhard K Keppler, Peter Rapta.   

Abstract

A modified paullone ligand bearing a TEMPO free-radical unit (HL) and its ruthenium(II) and osmium(II)-arene complexes [M(p-cymene)(HL)Cl]Cl·nH(2)O (M = Ru, Os) exhibit high antiproliferative activity in human cancer cell lines.

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Year:  2012        PMID： 22797078     DOI： 10.1039/c2cc33786j

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  10 in total

1.  A comparative DFT study on aquation and nucleobase binding of ruthenium (II) and osmium (II) arene complexes.

Authors:  Hanlu Wang; Xingye Zeng; Rujin Zhou; Cunyuan Zhao
Journal:  J Mol Model       Date:  2013-09-15       Impact factor: 1.810

2.  Metal-Arene Complexes with Indolo[3,2-c]-quinolines: Effects of Ruthenium vs Osmium and Modifications of the Lactam Unit on Intermolecular Interactions, Anticancer Activity, Cell Cycle, and Cellular Accumulation.

Authors:  Lukas K Filak; Simone Göschl; Petra Heffeter; Katia Ghannadzadeh Samper; Alexander E Egger; Michael A Jakupec; Bernhard K Keppler; Walter Berger; Vladimir B Arion
Journal:  Organometallics       Date:  2013-01-17       Impact factor: 3.876

3.  Dicopper(II) and dizinc(II) complexes with nonsymmetric dinucleating ligands based on indolo[3,2-c]quinolines: synthesis, structure, cytotoxicity, and intracellular distribution.

Authors:  Michael F Primik; Simone Göschl; Samuel M Meier; Nadine Eberherr; Michael A Jakupec; Éva A Enyedy; Ghenadie Novitchi; Vladimir B Arion
Journal:  Inorg Chem       Date:  2013-08-16       Impact factor: 5.165

4.  Effect of the piperazine unit and metal-binding site position on the solubility and anti-proliferative activity of ruthenium(II)- and osmium(II)- arene complexes of isomeric indolo[3,2-c]quinoline-piperazine hybrids.

Authors:  Lukas K Filak; Danuta S Kalinowski; Theresa J Bauer; Des R Richardson; Vladimir B Arion
Journal:  Inorg Chem       Date:  2014-06-13       Impact factor: 5.165

5.  Mitochondria-targeted spin-labelled luminescent iridium anticancer complexes.

Authors:  V Venkatesh; Raul Berrocal-Martin; Christopher J Wedge; Isolda Romero-Canelón; Carlos Sanchez-Cano; Ji-Inn Song; James P C Coverdale; Pingyu Zhang; Guy J Clarkson; Abraha Habtemariam; Steven W Magennis; Robert J Deeth; Peter J Sadler
Journal:  Chem Sci       Date:  2017-10-20       Impact factor: 9.825

6.  Ready access to 7,8-dihydroindolo[2,3-d][1]benzazepine-6(5H)-one scaffold and analogues via early-stage Fischer ring-closure reaction.

Authors:  Irina Kuznetcova; Felix Bacher; Daniel Vegh; Hsiang-Yu Chuang; Vladimir B Arion
Journal:  Beilstein J Org Chem       Date:  2022-01-26       Impact factor: 2.883

7.  Alsterpaullone, a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells through Apoptosis-Inducing Effect.

Authors:  Chunying Cui; Yuji Wang; Yaonan Wang; Ming Zhao; Shiqi Peng
Journal:  J Anal Methods Chem       Date:  2013-03-12       Impact factor: 2.193

8.  A highly cytotoxic modified paullone ligand bearing a TEMPO free-radical unit and its copper(II) complex as potential hR2 RNR inhibitors.

Authors:  Anatolie Dobrov; Simone Göschl; Michael A Jakupec; Ana Popović-Bijelić; Astrid Gräslund; Peter Rapta; Vladimir B Arion
Journal:  Chem Commun (Camb)       Date:  2013-11-04       Impact factor: 6.222

9.  Os2 -Os4 Switch Controls DNA Knotting and Anticancer Activity.

Authors:  Ying Fu; María J Romero; Luca Salassa; Xi Cheng; Abraha Habtemariam; Guy J Clarkson; Ivan Prokes; Alison Rodger; Giovanni Costantini; Peter J Sadler
Journal:  Angew Chem Int Ed Engl       Date:  2016-05-30       Impact factor: 15.336

10.  Highly Antiproliferative Latonduine and Indolo[2,3-c]quinoline Derivatives: Complex Formation with Copper(II) Markedly Changes the Kinase Inhibitory Profile.

Authors:  Christopher Wittmann; Felix Bacher; Eva A Enyedy; Orsolya Dömötör; Gabriella Spengler; Christian Madejski; Jóhannes Reynisson; Vladimir B Arion
Journal:  J Med Chem       Date:  2022-02-01       Impact factor: 7.446
  10 in total

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