AIM: Fibroblast growth factor 7 (FGF7) is involved in a number of physiological and pathological processes, including lung disease. However, relatively little is known about the effect of FGF7 gene polymorphisms on chronic obstructive pulmonary disease (COPD) susceptibility. This study aimed to investigate the association between FGF7 polymorphisms with COPD susceptibility in a Chinese Han population. METHODS: We conducted a case-control study of 279 COPD patients and 367 age- and gender-distribution-matched control subjects. The tagging SNPs rs10519225 and rs7170426 in FGF7 were genotyped by SNaPshot. The associations of each SNP genotype and haplotype constructed by these loci with COPD were analyzed. RESULTS: A multivariate analysis showed that rs10519225 was significantly associated with an increased risk of COPD (P=0.011, OR=1.535, FDR q=0.022), whereas no association was found for rs7170426. Linkage disequilibrium (LD) analysis showed that these loci were in weak LD, with an r(2) of 0.033 and a D' of 0.232 (95% CI: 0.150-0.520). The haplotype constructed by allele G at rs10519225 and allele A at rs7170426 was associated with a decreased susceptibility to COPD (P=0.012, OR=0.751, FDR q=0.048). CONCLUSION: These findings suggest that FGF7 may be one susceptibility factor for COPD.
AIM: Fibroblast growth factor 7 (FGF7) is involved in a number of physiological and pathological processes, including lung disease. However, relatively little is known about the effect of FGF7 gene polymorphisms on chronic obstructive pulmonary disease (COPD) susceptibility. This study aimed to investigate the association between FGF7 polymorphisms with COPD susceptibility in a Chinese Han population. METHODS: We conducted a case-control study of 279 COPDpatients and 367 age- and gender-distribution-matched control subjects. The tagging SNPs rs10519225 and rs7170426 in FGF7 were genotyped by SNaPshot. The associations of each SNP genotype and haplotype constructed by these loci with COPD were analyzed. RESULTS: A multivariate analysis showed that rs10519225 was significantly associated with an increased risk of COPD (P=0.011, OR=1.535, FDR q=0.022), whereas no association was found for rs7170426. Linkage disequilibrium (LD) analysis showed that these loci were in weak LD, with an r(2) of 0.033 and a D' of 0.232 (95% CI: 0.150-0.520). The haplotype constructed by allele G at rs10519225 and allele A at rs7170426 was associated with a decreased susceptibility to COPD (P=0.012, OR=0.751, FDR q=0.048). CONCLUSION: These findings suggest that FGF7 may be one susceptibility factor for COPD.
Authors: Bridget M Riley; M Adela Mansilla; Jinghong Ma; Sandra Daack-Hirsch; Brion S Maher; Lisa M Raffensperger; Erilynn T Russo; Alexandre R Vieira; Catherine Dodé; Moosa Mohammadi; Mary L Marazita; Jeffrey C Murray Journal: Proc Natl Acad Sci U S A Date: 2007-03-06 Impact factor: 11.205
Authors: W S Simonet; M L DeRose; N Bucay; H Q Nguyen; S E Wert; L Zhou; T R Ulich; A Thomason; D M Danilenko; J A Whitsett Journal: Proc Natl Acad Sci U S A Date: 1995-12-19 Impact factor: 11.205
Authors: Jemma B Wilk; Ting-Hsu Chen; Daniel J Gottlieb; Robert E Walter; Michael W Nagle; Brian J Brandler; Richard H Myers; Ingrid B Borecki; Edwin K Silverman; Scott T Weiss; George T O'Connor Journal: PLoS Genet Date: 2009-03-20 Impact factor: 5.917
Authors: Sreekumar G Pillai; Dongliang Ge; Guohua Zhu; Xiangyang Kong; Kevin V Shianna; Anna C Need; Sheng Feng; Craig P Hersh; Per Bakke; Amund Gulsvik; Andreas Ruppert; Karin C Lødrup Carlsen; Allen Roses; Wayne Anderson; Stephen I Rennard; David A Lomas; Edwin K Silverman; David B Goldstein Journal: PLoS Genet Date: 2009-03-20 Impact factor: 5.917