| Literature DB >> 22796385 |
Joachim Rassow1, Michael Meinecke.
Abstract
The vacuolating cytotoxin VacA, a polypeptide of about 88 kDa, is one of the major virulence factors of Helicobacter pylori. VacA essentially acts as an invasive chloride channel targeting mitochondria. The results of recent studies open a new perspective on the mechanisms by which VacA causes loss of the mitochondrial membrane potential, mitochondrial fragmentation, formation of reactive oxygen species, autophagy, cell death and gastric cancer.Entities:
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Year: 2012 PMID： 22796385 DOI： 10.1016/j.micinf.2012.07.002
Source DB: PubMed Journal: Microbes Infect ISSN： 1286-4579 Impact factor: 2.700