Literature DB >> 22795899

New oxirane derivatives of 1,4-naphthoquinones and their evaluation against T. cruzi epimastigote forms.

Paula F Carneiro1, Samara B do Nascimento, Antonio V Pinto, Maria do Carmo F R Pinto, Guilherme C Lechuga, Dilvani O Santos, Helvécio M dos Santos Júnior, Jackson A L C Resende, Saulo C Bourguignon, Vitor F Ferreira.   

Abstract

New oxirane derivatives were synthesized using six naphthoquinones as the starting materials. Our biological results showed that these oxiranes acted as trypanocidal agents against Trypanosoma cruzi with minimal cytotoxicity in the VERO cell line compared to naphthoquinones. In particular, oxirane derivative 14 showed low cytotoxicity in a mammalian cell line and exhibited better activity against epimastigote forms of T.cruzi than the current drug used to treat Chagas disease, benznidazole.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 22795899     DOI： 10.1016/j.bmc.2012.06.027

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  6 in total

1.  Interactions between 4-aminoquinoline and heme: Promising mechanism against Trypanosoma cruzi.

Authors:  Guilherme Curty Lechuga; Júlio Cesar Borges; Claudia Magalhães Calvet; Humberto Pinheiro de Araújo; Aline Araujo Zuma; Samara Braga do Nascimento; Maria Cristina Machado Motta; Alice Maria Rolim Bernardino; Mirian Claudia de Souza Pereira; Saulo Cabral Bourguignon
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2016-07-14       Impact factor: 4.077

2.  Evidence for Tissue Toxicity in BALB/c Exposed to a Long-Term Treatment with Oxiranes Compared to Meglumine Antimoniate.

Authors:  Luiz Filipe Gonçalves Oliveira; Franklin Souza-Silva; Léa Cysne-Finkelstein; Kíssila Rabelo; Juliana Fernandes Amorim; Adriana de Souza Azevedo; Saulo Cabral Bourguignon; Vitor Francisco Ferreira; Marciano Viana Paes; Carlos Roberto Alves
Journal:  Biomed Res Int       Date:  2017-07-17       Impact factor: 3.411

3.  In Vitro Inhibition of Helicobacter pylori Growth by Redox Cycling Phenylaminojuglones.

Authors:  Julio Benites; Héctor Toledo; Felipe Salas; Angélica Guerrero; David Rios; Jaime A Valderrama; Pedro Buc Calderon
Journal:  Oxid Med Cell Longev       Date:  2018-04-24       Impact factor: 6.543

4.  In Silico Insights into the Mechanism of Action of Epoxy-α-Lapachone and Epoxymethyl-Lawsone in Leishmania spp.

Authors:  Juliana Figueiredo Peixoto; Adriane da Silva Oliveira; Patrícia Queiroz Monteiro; Luiz Filipe Gonçalves-Oliveira; Valter Viana Andrade-Neto; Vitor Francisco Ferreira; Franklin Souza-Silva; Carlos Roberto Alves
Journal:  Molecules       Date:  2021-06-10       Impact factor: 4.411

5.  Potential of 2-hydroxy-3-phenylsulfanylmethyl-[1,4]-naphthoquinones against Leishmania (L.) infantum: biological activity and structure-activity relationships.

Authors:  Erika G Pinto; Isabela O Santos; Thomas J Schmidt; Samanta E T Borborema; Vitor F Ferreira; David R Rocha; Andre G Tempone
Journal:  PLoS One       Date:  2014-08-29       Impact factor: 3.240

6.  Antileishmanial Activity of 2-Methoxy-4H-spiro-[naphthalene-1,2'-oxiran]-4-one (Epoxymethoxy-lawsone): A Promising New Drug Candidate for Leishmaniasis Treatment.

Authors:  Luiz Filipe Gonçalves Oliveira; Franklin Souza-Silva; Luzia Monteiro de Castro Côrtes; Lea Cysne-Finkelstein; Mirian Cláudia de Souza Pereira; Francisco Odêncio de Oliveira Junior; Rosa Teixeira Pinho; Suzana Corte Real; Saulo Cabral Bourguignon; Vitor Francisco Ferreira; Carlos Roberto Alves
Journal:  Molecules       Date:  2018-04-10       Impact factor: 4.411
  6 in total

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