OBJECTIVE: To predict presence of invasive component and nodal involvement in women diagnosed preoperatively with ductal carcinoma in situ (DCIS) by vacuum-assisted breast biopsy (VABB). MATERIALS AND METHODS: We retrospectively analyzed 733 patients with preoperatively diagnosed DCIS, investigating the association of clinical-radiological variables with invasive component and nodal involvement. RESULTS: Mammographic size >20 mm and residual lesion on post-VABB mammogram were related to invasive component (both p < 0.0001) and nodal involvement (p = 0.001, p = 0.03). Age <40 years was associated with presence of invasive component (p = 0.003). By multivariate analysis residual disease was associated with invasive component, and mammographic tumor size >20 mm with nodal involvement, both highly significant. CONCLUSIONS: Older age, lesion <20 mm, and no residual lesion predict absence of invasion and no nodal involvement in VABB-diagnosed DCIS. However it would be imprudent to routinely forego sentinel node biopsy in such patients as non-negligible proportions of them have invasive disease.
OBJECTIVE: To predict presence of invasive component and nodal involvement in women diagnosed preoperatively with ductal carcinoma in situ (DCIS) by vacuum-assisted breast biopsy (VABB). MATERIALS AND METHODS: We retrospectively analyzed 733 patients with preoperatively diagnosed DCIS, investigating the association of clinical-radiological variables with invasive component and nodal involvement. RESULTS: Mammographic size >20 mm and residual lesion on post-VABB mammogram were related to invasive component (both p < 0.0001) and nodal involvement (p = 0.001, p = 0.03). Age <40 years was associated with presence of invasive component (p = 0.003). By multivariate analysis residual disease was associated with invasive component, and mammographic tumor size >20 mm with nodal involvement, both highly significant. CONCLUSIONS: Older age, lesion <20 mm, and no residual lesion predict absence of invasion and no nodal involvement in VABB-diagnosed DCIS. However it would be imprudent to routinely forego sentinel node biopsy in such patients as non-negligible proportions of them have invasive disease.
Authors: Michael R Harowicz; Ashirbani Saha; Lars J Grimm; P Kelly Marcom; Jeffrey R Marks; E Shelley Hwang; Maciej A Mazurowski Journal: J Magn Reson Imaging Date: 2017-02-09 Impact factor: 4.813
Authors: Tawakalitu O Oseni; Barbara L Smith; Constance D Lehman; Charmi A Vijapura; Niveditha Pinnamaneni; Manisha Bahl Journal: Ann Surg Oncol Date: 2020-05-16 Impact factor: 5.344
Authors: Rafael da Silva Sá; Angela Flávia Logullo; Simone Elias; Gil Facina; Vanessa Monteiro Sanvido; Afonso Celso Pinto Nazário Journal: Breast Cancer (Dove Med Press) Date: 2021-06-21
Authors: Suzanne C E Diepstraten; Stephanie M W Y van de Ven; Ruud M Pijnappel; Petra H M Peeters; Maurice A A J van den Bosch; Helena M Verkooijen; Sjoerd G Elias Journal: PLoS One Date: 2013-10-11 Impact factor: 3.240