| Literature DB >> 22795330 |
Raffaella Gandolfi1, Flavia Marinelli, Enzio Ragg, Diego Romano, Francesco Molinari.
Abstract
The chemoenzymatic deacylation of ramoplanin A2 is described for the first time: ramoplanin A2 was Boc-protected and hydrogenated to Boc-protected tetrahydroramoplanin, which was subsequently deacylated using an acylase from Actinoplanes utahensis NRRL 12052. The chemoenzymatic process proceeded with 80% overall yield, which favourably compares with the previously described chemical deacylation.Entities:
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Year: 2012 PMID： 22795330 DOI： 10.1016/j.bmcl.2012.06.046
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823