Literature DB >> 2279293

Ga-labeling of immunoglobulin G with high specific radioactivity.

T Furukawa1, Y Fujibayashi, M Fukunaga, A Yokoyama.   

Abstract

To obtain radiogallium labeled immunoglobulin G with a high specific radioactivity for in vitro use, a 67Ga source was purified by extraction from 67Ga-gallium citrate with butyl acetate, and a 67Ga-labeling solution was produced. This solution was then used to label a deferoxamine-immunoglobulin G conjugate. Both a very high specific radioactivity (872 +/- 56 MBq/mg) and a high labeling efficiency (94.0%) were achieved.

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Year:  1990        PMID: 2279293     DOI: 10.1248/cpb.38.2285

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN: 0009-2363            Impact factor:   1.645


  4 in total

1.  A simple method for the preparation of gallium chloride from the citrate solution.

Authors:  K Chan; I Gonda
Journal:  Eur J Nucl Med       Date:  1991

2.  The use of SEP-PAK SI cartridges for the preparation of gallium chloride from the citrate solution.

Authors:  V Scasnár; J E van Lier
Journal:  Eur J Nucl Med       Date:  1993-03

3.  Basic evaluation of 67Ga labeled digoxin derivative as a metal-labeled bifunctional radiopharmaceutical.

Authors:  Y Fujibayashi; Y Takemura; H Taniuchi; N Iijima; J Konishi; A Yokoyama
Journal:  Ann Nucl Med       Date:  1993-11       Impact factor: 2.668

4.  Applicability of short-lived radiometallic nuclide for high sensitivity two-site "sandwich" immunoradiometric assay: human growth hormone assay.

Authors:  K Horiuchi; L H Lin; Y Fujibayashi; V C Borghi; A Yokoyama
Journal:  Ann Nucl Med       Date:  1996-02       Impact factor: 2.668

  4 in total

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