OBJECTIVE: To describe the diagnostic validity of a gadolinium-enhanced routine brain MRI scan with 5 mm section thickness for the detection of optic nerve involvement in patients with retinoblastoma. METHODS: Medical records of primarily enucleated retinoblastoma patients who underwent routine preoperative brain MRI scan with section thickness of 5 mm were retrospectively reviewed. Preoperative magnetic resonance images were independently reviewed in a masked fashion by two radiologists and compared with histological findings. RESULTS: 41 eyes of 41 patients were included and the mean age at enucleation was 23.1 months. Among 41 eyes, 14 eyes were diagnosed to have post-laminar optic nerve invasion on histopathology. The accuracy, sensitivity and specificity of MRI for the diagnosis of post-laminar invasion were 73.2%, 35.7% and 92.6%, respectively, by the first radiologist and 78.0%, 42.9% and 96.3%, respectively, by the second radiologist. Moderate agreement was found between two radiologists (κ =0.48, p<0.01). CONCLUSIONS: Compared with the results of previous studies using orbital MRI with less than 3 mm section thickness, routine brain MRI with section thickness of 5 mm showed comparable specificity but inferior sensitivity in detecting optic nerve involvement of retinoblastoma.
OBJECTIVE: To describe the diagnostic validity of a gadolinium-enhanced routine brain MRI scan with 5 mm section thickness for the detection of optic nerve involvement in patients with retinoblastoma. METHODS: Medical records of primarily enucleated retinoblastomapatients who underwent routine preoperative brain MRI scan with section thickness of 5 mm were retrospectively reviewed. Preoperative magnetic resonance images were independently reviewed in a masked fashion by two radiologists and compared with histological findings. RESULTS: 41 eyes of 41 patients were included and the mean age at enucleation was 23.1 months. Among 41 eyes, 14 eyes were diagnosed to have post-laminar optic nerve invasion on histopathology. The accuracy, sensitivity and specificity of MRI for the diagnosis of post-laminar invasion were 73.2%, 35.7% and 92.6%, respectively, by the first radiologist and 78.0%, 42.9% and 96.3%, respectively, by the second radiologist. Moderate agreement was found between two radiologists (κ =0.48, p<0.01). CONCLUSIONS: Compared with the results of previous studies using orbital MRI with less than 3 mm section thickness, routine brain MRI with section thickness of 5 mm showed comparable specificity but inferior sensitivity in detecting optic nerve involvement of retinoblastoma.
Authors: Selma Sirin; Marc Schlamann; Klaus A Metz; Norbert Bornfeld; Bernd Schweiger; Markus Holdt; Petra Temming; Michael M Schuendeln; Sophia L Goericke Journal: Neuroradiology Date: 2015-06-04 Impact factor: 2.804
Authors: Hervé J Brisse; Pim de Graaf; Paolo Galluzzi; Kristel Cosker; Philippe Maeder; Sophia Göricke; Firazia Rodjan; Marcus C de Jong; Alexia Savignoni; Isabelle Aerts; Laurence Desjardins; Annette C Moll; Theodora Hadjistilianou; Paolo Toti; Paul van der Valk; Jonas A Castelijns; Xavier Sastre-Garau Journal: Eur Radiol Date: 2014-11-30 Impact factor: 5.315
Authors: Selma Sirin; Marc Schlamann; Klaus A Metz; Norbert Bornfeld; Bernd Schweiger; Markus Holdt; Petra Temming; Michael M Schuendeln; Sophia L Goericke Journal: Neuroradiology Date: 2015-05-08 Impact factor: 2.804
Authors: Usha Kim; Gunjan Rathi; Gunja Chowdhary; K G Srinavasan; R Shanthi; R S Prabhu Krishna Journal: Indian J Ophthalmol Date: 2019-12 Impact factor: 1.848