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Literature DB >> 22787030

The Aβ-induced NFAT apoptotic pathway is also activated by GSK-3 inhibition: implications for Alzheimer therapeutics.

Scott Ayton¹, Peng Lei.

Abstract

Entities: Disease Gene

Year: 2012 PMID： 22787030 PMCID： PMC6622266 DOI： 10.1523/JNEUROSCI.2143-12.2012

Source DB: PubMed Journal: J Neurosci ISSN： 0270-6474 Impact factor: 6.167

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11 in total

1. NF-AT activation requires suppression of Crm1-dependent export by calcineurin.

Authors: J Zhu; F McKeon
Journal: Nature Date: 1999-03-18 Impact factor: 49.962

2. NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy.

Authors: Raquel Gómez-Sintes; José J Lucas
Journal: J Clin Invest Date: 2010-06-07 Impact factor: 14.808

3. Regulation of NMDA receptor trafficking by amyloid-beta.

Authors: Eric M Snyder; Yi Nong; Claudia G Almeida; Surojit Paul; Timothy Moran; Eun Young Choi; Angus C Nairn; Michael W Salter; Paul J Lombroso; Gunnar K Gouras; Paul Greengard
Journal: Nat Neurosci Date: 2005-07-17 Impact factor: 24.884

4. Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation.

Authors: Hai-Yan Wu; Eloise Hudry; Tadafumi Hashimoto; Kishore Kuchibhotla; Anete Rozkalne; Zhanyun Fan; Tara Spires-Jones; Hong Xie; Michal Arbel-Ornath; Cynthia L Grosskreutz; Brian J Bacskai; Bradley T Hyman
Journal: J Neurosci Date: 2010-02-17 Impact factor: 6.167

5. Lithium trial in Alzheimer's disease: a randomized, single-blind, placebo-controlled, multicenter 10-week study.

Authors: Harald Hampel; Michael Ewers; Katharina Bürger; Peter Annas; Anette Mörtberg; Anna Bogstedt; Lutz Frölich; Johannes Schröder; Peter Schönknecht; Matthias W Riepe; Inga Kraft; Thomas Gasser; Thomas Leyhe; Hans-Jürgen Möller; Alexander Kurz; Hans Basun
Journal: J Clin Psychiatry Date: 2009-06 Impact factor: 4.384

6. Cognitive decline in Alzheimer's disease is associated with selective changes in calcineurin/NFAT signaling.

Authors: Hafiz Mohmmad Abdul; Michelle A Sama; Jennifer L Furman; Diana M Mathis; Tina L Beckett; Adam M Weidner; Ela S Patel; Irfan Baig; M Paul Murphy; Harry LeVine; Susan D Kraner; Christopher M Norris
Journal: J Neurosci Date: 2009-10-14 Impact factor: 6.167

7. GSK3 inhibitors show benefits in an Alzheimer's disease (AD) model of neurodegeneration but adverse effects in control animals.

Authors: Shuxin Hu; Aynun N Begum; Mychica R Jones; Mike S Oh; Walter K Beech; Beverly Hudspeth Beech; Fusheng Yang; Pingping Chen; Oliver J Ubeda; Peter C Kim; Peter Davies; Qiulan Ma; Greg M Cole; Sally A Frautschy
Journal: Neurobiol Dis Date: 2008-11-05 Impact factor: 5.996

8. Disrupted intracellular calcium regulates BACE1 gene expression via nuclear factor of activated T cells 1 (NFAT 1) signaling.

Authors: Hyun Jin Cho; Seok Min Jin; Hong Deuk Youn; Kyoon Huh; Inhee Mook-Jung
Journal: Aging Cell Date: 2007-12-05 Impact factor: 9.304

3. Lithium enhances the antitumour effect of temozolomide against TP53 wild-type glioblastoma cells via NFAT1/FasL signalling.

Authors: Sheng Han; Lingxuan Meng; Yang Jiang; Wen Cheng; Xinxin Tie; Junzhe Xia; Anhua Wu
Journal: Br J Cancer Date: 2017-03-30 Impact factor: 7.640

3 in total