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Literature DB >> 22787029

Insights into the cellular and molecular contributions of MeCP2 overexpression to disease pathophysiology.

M Morgan Taylor¹, Shachee Doshi.

Abstract

Entities: Chemical Disease Gene Species

Year: 2012 PMID： 22787029 PMCID： PMC3410636 DOI： 10.1523/JNEUROSCI.2043-12.2012

Source DB: PubMed Journal: J Neurosci ISSN： 0270-6474 Impact factor: 6.167

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12 in total

1. REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis.

Authors: Nurit Ballas; Christopher Grunseich; Diane D Lu; Joan C Speh; Gail Mandel
Journal: Cell Date: 2005-05-20 Impact factor: 41.582

2. Role of amyloid-beta glycine 33 in oligomerization, toxicity, and neuronal plasticity.

Authors: Anja Harmeier; Christian Wozny; Benjamin R Rost; Lisa-Marie Munter; Haiqing Hua; Oleg Georgiev; Michael Beyermann; Peter W Hildebrand; Christoph Weise; Walter Schaffner; Dietmar Schmitz; Gerd Multhaup
Journal: J Neurosci Date: 2009-06-10 Impact factor: 6.167

3. Progressive cerebellar degenerative changes in the severe mental retardation syndrome caused by duplication of MECP2 and adjacent loci on Xq28.

Authors: William Reardon; Veronica Donoghue; Anne-Marie Murphy; Mary D King; Philip D Mayne; Nina Horn; Lisbeth Birk Møller
Journal: Eur J Pediatr Date: 2010-02-23 Impact factor: 3.183

4. A mouse model for MeCP2 duplication syndrome: MeCP2 overexpression impairs learning and memory and synaptic transmission.

Authors: Elisa S Na; Erika D Nelson; Megumi Adachi; Anita E Autry; Melissa A Mahgoub; Ege T Kavalali; Lisa M Monteggia
Journal: J Neurosci Date: 2012-02-29 Impact factor: 6.167

5. Repressor element-1 silencing transcription factor (REST)-dependent epigenetic remodeling is critical to ischemia-induced neuronal death.

Authors: Kyung-Min Noh; Jee-Yeon Hwang; Antonia Follenzi; Rodoniki Athanasiadou; Takahiro Miyawaki; John M Greally; Michael V L Bennett; R Suzanne Zukin
Journal: Proc Natl Acad Sci U S A Date: 2012-02-27 Impact factor: 11.205

6. The Rett syndrome protein MeCP2 regulates synaptic scaling.

Authors: Zilong Qiu; Emily L Sylwestrak; David N Lieberman; Yan Zhang; Xin-Yu Liu; Anirvan Ghosh
Journal: J Neurosci Date: 2012-01-18 Impact factor: 6.167

7. Global ischemia induces downregulation of Glur2 mRNA and increases AMPA receptor-mediated Ca2+ influx in hippocampal CA1 neurons of gerbil.

Authors: J A Gorter; J J Petrozzino; E M Aronica; D M Rosenbaum; T Opitz; M V Bennett; J A Connor; R S Zukin
Journal: J Neurosci Date: 1997-08-15 Impact factor: 6.167

Insights into the cellular and molecular contributions of MeCP2 overexpression to disease pathophysiology.

1. REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis.

2. Role of amyloid-beta glycine 33 in oligomerization, toxicity, and neuronal plasticity.

3. Progressive cerebellar degenerative changes in the severe mental retardation syndrome caused by duplication of MECP2 and adjacent loci on Xq28.

4. A mouse model for MeCP2 duplication syndrome: MeCP2 overexpression impairs learning and memory and synaptic transmission.

5. Repressor element-1 silencing transcription factor (REST)-dependent epigenetic remodeling is critical to ischemia-induced neuronal death.

6. The Rett syndrome protein MeCP2 regulates synaptic scaling.

7. Global ischemia induces downregulation of Glur2 mRNA and increases AMPA receptor-mediated Ca2+ influx in hippocampal CA1 neurons of gerbil.

8. Isoform-specific toxicity of Mecp2 in postmitotic neurons: suppression of neurotoxicity by FoxG1.

Review 9. Failure of neuronal homeostasis results in common neuropsychiatric phenotypes.

10. MeCP2, a key contributor to neurological disease, activates and represses transcription.

1. Brain region-specific expression of MeCP2 isoforms correlates with DNA methylation within Mecp2 regulatory elements.