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Literature DB >> 22785560

Releasing the break on X chromosome inactivation: Rnf12/RLIM targets REX1 for degradation.

Abstract

One of the two X chromosomes in cells of female mammals is transcriptionally silenced in a process known as X chromosome inactivation (XCI). Initiation of XCI is regulated by the ubiquitin ligase Rnf12/RLIM, but the mechanisms by which Rnf12/RLIM mediates this process has been a mystery. A recent study by Gontan et al. shows that Rnf12/RLIM targets REX1, an inhibitor of XCI, for proteasomal degradation, providing an answer to this question.

Entities: Gene

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Year: 2012 PMID： 22785560 PMCID： PMC3494387 DOI： 10.1038/cr.2012.98

Source DB: PubMed Journal: Cell Res ISSN： 1001-0602 Impact factor: 25.617

16 in total

1. RNF12 initiates X-chromosome inactivation by targeting REX1 for degradation.

Authors: Cristina Gontan; Eskeatnaf Mulugeta Achame; Jeroen Demmers; Tahsin Stefan Barakat; Eveline Rentmeester; Wilfred van IJcken; J Anton Grootegoed; Joost Gribnau
Journal: Nature Date: 2012-04-29 Impact factor: 49.962

2. Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors.

Authors: Heather P Ostendorff; Reto I Peirano; Marvin A Peters; Anne Schlüter; Michael Bossenz; Martin Scheffner; Ingolf Bach
Journal: Nature Date: 2002-03-07 Impact factor: 49.962

3. RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex.

Authors: I Bach; C Rodriguez-Esteban; C Carrière; A Bhushan; A Krones; D W Rose; C K Glass; B Andersen; J C Izpisúa Belmonte; M G Rosenfeld
Journal: Nat Genet Date: 1999-08 Impact factor: 38.330

4. Expression of REX-1, a gene containing zinc finger motifs, is rapidly reduced by retinoic acid in F9 teratocarcinoma cells.

Authors: B A Hosler; G J LaRosa; J F Grippo; L J Gudas
Journal: Mol Cell Biol Date: 1989-12 Impact factor: 4.272

5. Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice.

Authors: Jongdae Shin; Michael Bossenz; Young Chung; Hong Ma; Meg Byron; Naoko Taniguchi-Ishigaki; Xiaochun Zhu; Baowei Jiao; Lisa L Hall; Michael R Green; Stephen N Jones; Irm Hermans-Borgmeyer; Jeanne B Lawrence; Ingolf Bach
Journal: Nature Date: 2010-10-21 Impact factor: 49.962

6. RNF12 is an X-Encoded dose-dependent activator of X chromosome inactivation.

Authors: Iris Jonkers; Tahsin Stefan Barakat; Eskeatnaf Mulugeta Achame; Kim Monkhorst; Annegien Kenter; Eveline Rentmeester; Frank Grosveld; J Anton Grootegoed; Joost Gribnau
Journal: Cell Date: 2009-11-25 Impact factor: 41.582

7. Analysis of Rex1 (zfp42) function in embryonic stem cell differentiation.

Authors: Kymora B Scotland; Siming Chen; Renia Sylvester; Lorraine J Gudas
Journal: Dev Dyn Date: 2009-08 Impact factor: 3.780

8. Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer.

Authors: Steven A Johnsen; Cenap Güngör; Tanja Prenzel; Sabine Riethdorf; Lutz Riethdorf; Naoko Taniguchi-Ishigaki; Thomas Rau; Baris Tursun; J David Furlow; Guido Sauter; Martin Scheffner; Klaus Pantel; Frank Gannon; Ingolf Bach
Journal: Cancer Res Date: 2009-01-01 Impact factor: 12.701