BACKGROUND: Although the incidence of ventricular tachyarrhythmias associated with structural heart disease is highest in winter and during the daytime, seasonal and circadian variations among cardiac events in patients with congenital long QT syndrome (LQTS) remain unknown. The present study aims to determine seasonal and circadian cardiac events in patients with a congenital LQTS genotype. METHODS AND RESULTS: The medical records of 196 consecutive patients with symptomatic LQTS (age, 32 ± 19 years; female, n=133; LQT1, n=86; LQT2, n=95; LQT3, n=15) who were genotyped between 1979 and 2006 at 2 major Japanese institutions were retrospectively analyzed. The patients with LQT1, LQT2, and LQT3 developed 223,550 and 59 cardiac events during a mean follow-up of 26, 33, and 25 years, respectively. The numbers of cardiac events significantly peaked during the summer among those with LQT1 (P<0.001) and from summer to fall in those with LQT2 (P<0.001), but reached the nadir in winter among those with LQT3 (P=0.003). Cardiac events significantly peaked in the afternoon (12:00-17:59) and morning (06:00-11:59) among those with LQT1 (P<0.001) and LQT2 (P<0.001). CONCLUSIONS: The frequency of cardiac events was specifically seasonal and circadian among patients with the 3 major genotypes of congenital LQTS.
BACKGROUND: Although the incidence of ventricular tachyarrhythmias associated with structural heart disease is highest in winter and during the daytime, seasonal and circadian variations among cardiac events in patients with congenital long QT syndrome (LQTS) remain unknown. The present study aims to determine seasonal and circadian cardiac events in patients with a congenital LQTS genotype. METHODS AND RESULTS: The medical records of 196 consecutive patients with symptomatic LQTS (age, 32 ± 19 years; female, n=133; LQT1, n=86; LQT2, n=95; LQT3, n=15) who were genotyped between 1979 and 2006 at 2 major Japanese institutions were retrospectively analyzed. The patients with LQT1, LQT2, and LQT3 developed 223,550 and 59 cardiac events during a mean follow-up of 26, 33, and 25 years, respectively. The numbers of cardiac events significantly peaked during the summer among those with LQT1 (P<0.001) and from summer to fall in those with LQT2 (P<0.001), but reached the nadir in winter among those with LQT3 (P=0.003). Cardiac events significantly peaked in the afternoon (12:00-17:59) and morning (06:00-11:59) among those with LQT1 (P<0.001) and LQT2 (P<0.001). CONCLUSIONS: The frequency of cardiac events was specifically seasonal and circadian among patients with the 3 major genotypes of congenital LQTS.
Authors: Brian P Delisle; John L Stumpf; Jennifer L Wayland; Sidney R Johnson; Makoto Ono; Dalton Hall; Don E Burgess; Elizabeth A Schroder Journal: Curr Opin Pharmacol Date: 2020-11-09 Impact factor: 5.547
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Authors: Brian P Delisle; Alfred L George; Jeanne M Nerbonne; Joseph T Bass; Crystal M Ripplinger; Mukesh K Jain; Tracey O Hermanstyne; Martin E Young; Prince J Kannankeril; Jeanne F Duffy; Joshua I Goldhaber; Martica H Hall; Virend K Somers; Michael H Smolensky; Christine E Garnett; Ron C Anafi; Frank A J L Scheer; Kalyanam Shivkumar; Steven A Shea; Ravi C Balijepalli Journal: Circ Arrhythm Electrophysiol Date: 2021-11-01
Authors: Christina Y Miyake; S Yukiko Asaki; Gregory Webster; Richard J Czosek; Joseph Atallah; Kishor Avasarala; Sri O Rao; Patricia E Thomas; Jeffrey J Kim; Santiago O Valdes; Caridad de la Uz; Yunfei Wang; Xander H T Wehrens; Dominic Abrams Journal: JACC Clin Electrophysiol Date: 2017-08-30
Authors: Reena Mehra; Olga A Tjurmina; Olujimi A Ajijola; Rishi Arora; Donald C Bolser; Mark W Chapleau; Peng-Sheng Chen; Colleen E Clancy; Brian P Delisle; Michael R Gold; Jeffrey J Goldberger; David S Goldstein; Beth A Habecker; M Louis Handoko; Robert Harvey; James P Hummel; Thomas Hund; Christian Meyer; Susan Redline; Crystal M Ripplinger; Marc A Simon; Virend K Somers; Stavros Stavrakis; Thomas Taylor-Clark; Bradley Joel Undem; Richard L Verrier; Irving H Zucker; George Sopko; Kalyanam Shivkumar Journal: JACC Basic Transl Sci Date: 2022-01-26
Authors: Peter M Kekenes-Huskey; Don E Burgess; Bin Sun; Daniel C Bartos; Ezekiel R Rozmus; Corey L Anderson; Craig T January; Lee L Eckhardt; Brian P Delisle Journal: Int J Mol Sci Date: 2022-07-02 Impact factor: 6.208