Literature DB >> 22785080

Radiolabeled γ-AApeptides: a new class of tracers for positron emission tomography.

Yunan Yang1, Youhong Niu, Hao Hong, Haifan Wu, Yin Zhang, Jonathan W Engle, Todd E Barnhart, Jianfeng Cai, Weibo Cai.   

Abstract

A γ-AApeptide-based tracer for positron emission tomography imaging of integrin α(v)β(3) is reported. Despite its shorter sequence and linear nature, this tracer had comparable integrin α(v)β(3) binding affinity to the cyclic arginine-glycine-aspartic acid peptide but significantly higher resistance to enzymatic degradation and better stability.

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Year:  2012        PMID： 22785080      PMCID： PMC3397393          DOI： 10.1039/c2cc33620k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  15 in total

1.  Design and synthesis of AApeptides: a new class of peptide mimics.

Authors:  Yaogang Hu; Xiaolong Li; Said M Sebti; Jiandong Chen; Jianfeng Cai
Journal:  Bioorg Med Chem Lett       Date:  2011-01-07       Impact factor: 2.823

Review 2.  Anti-angiogenic cancer therapy based on integrin alphavbeta3 antagonism.

Authors:  Weibo Cai; Xiaoyuan Chen
Journal:  Anticancer Agents Med Chem       Date:  2006-09       Impact factor: 2.505

3.  In vitro and in vivo characterization of 64Cu-labeled Abegrin, a humanized monoclonal antibody against integrin alpha v beta 3.

Authors:  Weibo Cai; Yun Wu; Kai Chen; Qizhen Cao; David A Tice; Xiaoyuan Chen
Journal:  Cancer Res       Date:  2006-10-01       Impact factor: 12.701

Review 4.  Tumor angiogenesis: therapeutic implications.

Authors:  J Folkman
Journal:  N Engl J Med       Date:  1971-11-18       Impact factor: 91.245

5.  γ-AApeptides bind to RNA by mimicking RNA-binding proteins.

Authors:  Youhong Niu; Alisha Jonesy Jones; Haifan Wu; Gabriele Varani; Jianfeng Cai
Journal:  Org Biomol Chem       Date:  2011-08-08       Impact factor: 3.876

6.  Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects.

Authors:  Weibo Cai; Dong-Woon Shin; Kai Chen; Olivier Gheysens; Qizhen Cao; Shan X Wang; Sanjiv S Gambhir; Xiaoyuan Chen
Journal:  Nano Lett       Date:  2006-04       Impact factor: 11.189

Review 7.  Imaging of integrins as biomarkers for tumor angiogenesis.

Authors:  Weibo Cai; Gang Niu; Xiaoyuan Chen
Journal:  Curr Pharm Des       Date:  2008       Impact factor: 3.116

Review 8.  Imaging in the era of molecular oncology.

Authors:  Ralph Weissleder; Mikael J Pittet
Journal:  Nature       Date:  2008-04-03       Impact factor: 49.962

Review 9.  Multimodality molecular imaging of tumor angiogenesis.

Authors:  Weibo Cai; Xiaoyuan Chen
Journal:  J Nucl Med       Date:  2008-06       Impact factor: 10.057

10.  Noninvasive visualization of the activated alphavbeta3 integrin in cancer patients by positron emission tomography and [18F]Galacto-RGD.

Authors:  Roland Haubner; Wolfgang A Weber; Ambros J Beer; Eugenija Vabuliene; Daniel Reim; Mario Sarbia; Karl-Friedrich Becker; Michael Goebel; Rüdiger Hein; Hans-Jürgen Wester; Horst Kessler; Markus Schwaiger
Journal:  PLoS Med       Date:  2005-03-29       Impact factor: 11.069
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  12 in total

1.  PET of follicle-stimulating hormone receptor: broad applicability to cancer imaging.

Authors:  Hao Hong; Yongjun Yan; Sixiang Shi; Stephen A Graves; Lazura K Krasteva; Robert J Nickles; Min Yang; Weibo Cai
Journal:  Mol Pharm       Date:  2015-01-20       Impact factor: 4.939

Review 2.  The development of antimicrobial γ-AApeptides.

Authors:  Fengyu She; Olapeju Oyesiku; Peiguang Zhou; Shiming Zhuang; David W Koenig; Jianfeng Cai
Journal:  Future Med Chem       Date:  2016-06-10       Impact factor: 3.808

3.  γ-AApeptides: Design, Structure, and Applications.

Authors:  Yan Shi; Peng Teng; Peng Sang; Fengyu She; Lulu Wei; Jianfeng Cai
Journal:  Acc Chem Res       Date:  2016-02-22       Impact factor: 22.384

Review 4.  Advances in Development of Antimicrobial Peptidomimetics as Potential Drugs.

Authors:  Natalia Molchanova; Paul R Hansen; Henrik Franzyk
Journal:  Molecules       Date:  2017-08-29       Impact factor: 4.411

Review 5.  Antimicrobial AApeptides.

Authors:  Peng Sang; Yan Shi; Peng Teng; Annie Cao; Hai Xu; Qi Li; Jianfeng Cai
Journal:  Curr Top Med Chem       Date:  2017       Impact factor: 3.295

6.  Identification of novel inhibitors that disrupt STAT3-DNA interaction from a γ-AApeptide OBOC combinatorial library.

Authors:  Peng Teng; Xiaolei Zhang; Haifan Wu; Qiao Qiao; Said M Sebti; Jianfeng Cai
Journal:  Chem Commun (Camb)       Date:  2014-06-25       Impact factor: 6.222

7.  γ-AApeptides as a New Class of Peptidomimetics.

Authors:  Peng Teng; Yan Shi; Peng Sang; Jianfeng Cai
Journal:  Chemistry       Date:  2016-03-04       Impact factor: 5.236

8.  Short antimicrobial lipo-α/γ-AA hybrid peptides.

Authors:  Yaqiong Li; Christina Smith; Haifan Wu; Peng Teng; Yan Shi; Shruti Padhee; Torey Jones; Anh-My Nguyen; Chuanhai Cao; Hang Yin; Jianfeng Cai
Journal:  Chembiochem       Date:  2014-08-28       Impact factor: 3.164

Review 9.  Developments with investigating descriptors for antimicrobial AApeptides and their derivatives.

Authors:  Olapeju Bolarinwa; Jianfeng Cai
Journal:  Expert Opin Drug Discov       Date:  2018-06-22       Impact factor: 6.098

10.  Design, synthesis and characterization of fMLF-mimicking AApeptides.

Authors:  Yaogang Hu; Ni Cheng; Haifan Wu; Samuel Kang; Richard D Ye; Jianfeng Cai
Journal:  Chembiochem       Date:  2014-09-15       Impact factor: 3.164
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