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Literature DB >> 22784557

Chemokine CXCL12 in neurodegenerative diseases: an SOS signal for stem cell-based repair.

Meizhang Li¹, James S Hale, Jeremy N Rich, Richard M Ransohoff, Justin D Lathia.

Abstract

The dynamic relation between stem cells and their niche governs self-renewal and progenitor cell deployment. The chemokine CXCL12 (C-X-C motif ligand 12) and its signaling receptor CXCR4 (C-X-C motif receptor 4) represent an important pathway that regulates homing and maintenance of stem cells in neural niches. Neural stem cells (NSCs) reside in specific niches where communication with blood vessels is regulated by CXCL12. In neurodegenerative diseases and brain tumors, reactive vasculature forms in response to diseased tissues to create new niches that secrete CXCL12, enhancing the recruitment of neural progenitor cells (NPCs) to lesion sites via long-range migration. These observations suggest that the CXCL12-CXCR4 axis maintains NSCs and serves as an emergent salvage signal for initiating endogenous stem cell-based tissue repair.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：

Year: 2012 PMID： 22784557 PMCID： PMC3461091 DOI： 10.1016/j.tins.2012.06.003

Source DB: PubMed Journal: Trends Neurosci ISSN： 0166-2236 Impact factor: 13.837

109 in total

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Journal: Immunity Date: 2006-12 Impact factor: 31.745

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Journal: Cancer Res Date: 2006-08-15 Impact factor: 12.701

4. Expression of SDF-1 and CXCR4 during reorganization of the postnatal dentate gyrus.

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Journal: Dev Neurosci Date: 2007 Impact factor: 2.984

5. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response.

Authors: Shideng Bao; Qiulian Wu; Roger E McLendon; Yueling Hao; Qing Shi; Anita B Hjelmeland; Mark W Dewhirst; Darell D Bigner; Jeremy N Rich
Journal: Nature Date: 2006-10-18 Impact factor: 49.962

6. Role of stromal-derived factor-1alpha in the induction of circulating CD34+CXCR4+ progenitor cells after cardiac surgery.

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7. A role for CXCL12 (SDF-1alpha) in the pathogenesis of multiple sclerosis: regulation of CXCL12 expression in astrocytes by soluble myelin basic protein.

Authors: Tina M Calderon; Eliseo A Eugenin; Lillie Lopez; Sridhar Sampath Kumar; Joseph Hesselgesser; Cedric S Raine; Joan W Berman
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8. Tumor stromal-derived factor-1 recruits vascular progenitors to mitotic neovasculature, where microenvironment influences their differentiated phenotypes.

Authors: Manish Aghi; Kenneth S Cohen; Rachael J Klein; David T Scadden; E Antonio Chiocca
Journal: Cancer Res Date: 2006-09-15 Impact factor: 12.701

9. Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma.

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10. A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development.

Authors: Jennifer M Burns; Bretton C Summers; Yu Wang; Anita Melikian; Rob Berahovich; Zhenhua Miao; Mark E T Penfold; Mary Jean Sunshine; Dan R Littman; Calvin J Kuo; Kevin Wei; Brian E McMaster; Kim Wright; Maureen C Howard; Thomas J Schall
Journal: J Exp Med Date: 2006-08-28 Impact factor: 14.307

36 in total

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Journal: Sultan Qaboos Univ Med J Date: 2015-08-24

2. PAX3 Promotes Cell Migration and CXCR4 Gene Expression in Neural Crest Cells.

Authors: Man Xu; Yongle Li; Jinfeng Du; Hengrong Lin; Sixian Cao; Zuming Mao; Ronghua Wu; Mei Liu; Yan Liu; Qiyou Yin
Journal: J Mol Neurosci Date: 2017-11-13 Impact factor: 3.444

3. Induced pluripotent stem cells without c-Myc ameliorate retinal oxidative damage via paracrine effects and reduced oxidative stress in rats.

Authors: I-Mo Fang; Chang-Hao Yang; Shih-Hwa Chiou; Chung-May Yang
Journal: J Ocul Pharmacol Ther Date: 2014-08-14 Impact factor: 2.671

4. Elevated Serum Levels of CXC Chemokine Ligand-12 Are Associated with Unfavorable Functional Outcome and Mortality at 6-Month Follow-up in Chinese Patients with Acute Ischemic Stroke.

Authors: Xuan Cheng; Ya-Jun Lian; Yun-Qing Ma; Nan-Chang Xie; Chuan-Jie Wu
Journal: Mol Neurobiol Date: 2016-01-16 Impact factor: 5.590

Review 5. Mechanisms of cell-cell interaction in oligodendrogenesis and remyelination after stroke.

Authors: Kanako Itoh; Takakuni Maki; Josephine Lok; Ken Arai
Journal: Brain Res Date: 2015-05-08 Impact factor: 3.252

6. CXCL12/CXCR4 axis induces proliferation and invasion in human endometrial cancer.

Authors: Pingping Liu; Ping Long; Yu Huang; Fengyi Sun; Zhenyan Wang
Journal: Am J Transl Res Date: 2016-04-15 Impact factor: 4.060

7. Stichopus japonicus Polysaccharide, Fucoidan, or Heparin Enhanced the SDF-1α/CXCR4 Axis and Promoted NSC Migration via Activation of the PI3K/Akt/FOXO3a Signaling Pathway.

Authors: Chao Cui; Peng Wang; Ningshan Cui; Shuliang Song; Hao Liang; Aiguo Ji
Journal: Cell Mol Neurobiol Date: 2016-02-17 Impact factor: 5.046