| Literature DB >> 22784019 |
Katherine A Lyseng-Williamson1, James E Frampton.
Abstract
Intramuscular onabotulinumtoxinA (onaBoNTA; BOTOX®) is indicated for headache prophylaxis in adults with chronic migraine. According to pooled results from two large trials, treatment with up to five cycles of onaBoNTA (155-195 units/cycle) at 12-week intervals was effective in reducing headache symptoms, decreasing headache-related disability and improving health-related quality of life in patients with chronic migraine. OnaBoNTA was generally well tolerated in these trials, with an adverse event profile that was consistent with that of the neurotoxin when injected into head and neck muscles.Entities:
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Year: 2012 PMID: 22784019 DOI: 10.2165/11208930-000000000-00000
Source DB: PubMed Journal: CNS Drugs ISSN: 1172-7047 Impact factor: 5.749