Literature DB >> 22783990

A five-step synthesis of (±)-tylophorine via a nitrile-stabilized ammonium ylide.

Günther Lahm1, Alexander Stoye, Till Opatz.   

Abstract

The Stevens rearrangement of a nitrile-stabilized ammonium ylide is the key step of a very short and practical synthesis of the phenanthroindolizine alkaloid (±)-tylophorine. The method requires only five linear steps and is devoid of any protecting group manipulations.

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Year:  2012        PMID： 22783990     DOI： 10.1021/jo3011045

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  3 in total

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Journal:  iScience       Date:  2021-02-20

Review 2.  The reductive decyanation reaction: an overview and recent developments.

Authors:  Jean-Marc R Mattalia
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  3 in total

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