Literature DB >> 22782469

Quorum sensing inhibition in Pseudomonas aeruginosa PAO1 by antagonistic compound phenylacetic acid.

Khadar Syed Musthafa1, Bhagavathi Sundaram Sivamaruthi, Shunmugiah Karutha Pandian, Arumugam Veera Ravi.   

Abstract

In Pseudomonas aeruginosa, quorum sensing (QS) autoinducer known as acyl homoserine lactone (AHL) acts as a key regulator in the expression of pathogenic characters. In this work, the efficiency of phenylacetic acid (PAA) in reducing the production of AHL-dependent factors in P. aeruginosa PAO1 was studied. PAA at a concentration of 200 μg ml(-1) displayed significant reduction in QS-dependent pyocyanin, exopolysaccharide, and protease and elastase production in PAO1. In swimming inhibition assay, PAA-treated PAO1 cells exhibited poor motility in swimming agar plate. In in vivo analysis, PAO1-preinfected Caenorhabditis elegans showed enhanced survival when treated with PAA. PAA at the QS inhibitory concentration showed no growth inhibitory activity on PAO1. Results of the present study revealed the potential of PAA as antipathogenic compound to prevent QS-dependent pathogenicity of P. aeruginosa.

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Year:  2012        PMID： 22782469     DOI： 10.1007/s00284-012-0181-9

Source DB:  PubMed          Journal:  Curr Microbiol        ISSN： 0343-8651            Impact factor:   2.188


  28 in total

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Review 5.  Regulation of gene expression by cell-to-cell communication: acyl-homoserine lactone quorum sensing.

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Journal:  Annu Rev Genet       Date:  2001       Impact factor: 16.830

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Journal:  J Bacteriol       Date:  1980-06       Impact factor: 3.490

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Journal:  Science       Date:  1995-06-30       Impact factor: 63.714
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6.  The Phenylacetic Acid Catabolic Pathway Regulates Antibiotic and Oxidative Stress Responses in Acinetobacter.

Authors:  Anna J Hooppaw; Jenna C McGuffey; Gisela Di Venanzio; Juan C Ortiz-Marquez; Brent S Weber; Tasia Joy Lightly; Tim van Opijnen; Nichollas E Scott; Silvia T Cardona; Mario F Feldman
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Review 7.  Beyond Traditional Antimicrobials: A Caenorhabditis elegans Model for Discovery of Novel Anti-infectives.

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9.  Mycofabricated biosilver nanoparticles interrupt Pseudomonas aeruginosa quorum sensing systems.

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10.  Valproic Acid Induces Antimicrobial Compound Production in Doratomyces microspores.

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