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Literature DB >> 22781684

New lysine methyltransferase drug targets in cancer.

Tobias Wagner, Manfred Jung.

Abstract

Entities: Disease

Mesh：

Substances：

Year: 2012 PMID： 22781684 DOI： 10.1038/nbt.2300

Source DB: PubMed Journal: Nat Biotechnol ISSN： 1087-0156 Impact factor: 54.908

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13 in total

1. Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia.

Authors: Tino Schenk; Weihsu Claire Chen; Stefanie Göllner; Louise Howell; Liqing Jin; Katja Hebestreit; Hans-Ulrich Klein; Andreea C Popescu; Alan Burnett; Ken Mills; Robert A Casero; Laurence Marton; Patrick Woster; Mark D Minden; Martin Dugas; Jean C Y Wang; John E Dick; Carsten Müller-Tidow; Kevin Petrie; Arthur Zelent
Journal: Nat Med Date: 2012-03-11 Impact factor: 53.440

2. Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas.

Authors: Christopher J Sneeringer; Margaret Porter Scott; Kevin W Kuntz; Sarah K Knutson; Roy M Pollock; Victoria M Richon; Robert A Copeland
Journal: Proc Natl Acad Sci U S A Date: 2010-11-15 Impact factor: 11.205

3. Structural basis of substrate methylation and inhibition of SMYD2.

Authors: Andrew D Ferguson; Nicholas A Larsen; Tina Howard; Hannah Pollard; Isabelle Green; Christie Grande; Tony Cheung; Renee Garcia-Arenas; Scott Cowen; Jiaquan Wu; Robert Godin; Huawei Chen; Nicholas Keen
Journal: Structure Date: 2011-07-21 Impact factor: 5.006

4. Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.

Authors: Scott R Daigle; Edward J Olhava; Carly A Therkelsen; Christina R Majer; Christopher J Sneeringer; Jeffrey Song; L Danielle Johnston; Margaret Porter Scott; Jesse J Smith; Yonghong Xiao; Lei Jin; Kevin W Kuntz; Richard Chesworth; Mikel P Moyer; Kathrin M Bernt; Jen-Chieh Tseng; Andrew L Kung; Scott A Armstrong; Robert A Copeland; Victoria M Richon; Roy M Pollock
Journal: Cancer Cell Date: 2011-07-12 Impact factor: 31.743

5. A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells.

Authors: Masoud Vedadi; Dalia Barsyte-Lovejoy; Feng Liu; Sylvie Rival-Gervier; Abdellah Allali-Hassani; Viviane Labrie; Tim J Wigle; Peter A Dimaggio; Gregory A Wasney; Alena Siarheyeva; Aiping Dong; Wolfram Tempel; Sun-Chong Wang; Xin Chen; Irene Chau; Thomas J Mangano; Xi-Ping Huang; Catherine D Simpson; Samantha G Pattenden; Jacqueline L Norris; Dmitri B Kireev; Ashutosh Tripathy; Aled Edwards; Bryan L Roth; William P Janzen; Benjamin A Garcia; Arturas Petronis; James Ellis; Peter J Brown; Stephen V Frye; Cheryl H Arrowsmith; Jian Jin
Journal: Nat Chem Biol Date: 2011-07-10 Impact factor: 15.040

6. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia.

Authors: Jinghui Zhang; Li Ding; Linda Holmfeldt; Gang Wu; Sue L Heatley; Debbie Payne-Turner; John Easton; Xiang Chen; Jianmin Wang; Michael Rusch; Charles Lu; Shann-Ching Chen; Lei Wei; J Racquel Collins-Underwood; Jing Ma; Kathryn G Roberts; Stanley B Pounds; Anatoly Ulyanov; Jared Becksfort; Pankaj Gupta; Robert Huether; Richard W Kriwacki; Matthew Parker; Daniel J McGoldrick; David Zhao; Daniel Alford; Stephen Espy; Kiran Chand Bobba; Guangchun Song; Deqing Pei; Cheng Cheng; Stefan Roberts; Michael I Barbato; Dario Campana; Elaine Coustan-Smith; Sheila A Shurtleff; Susana C Raimondi; Maria Kleppe; Jan Cools; Kristin A Shimano; Michelle L Hermiston; Sergei Doulatov; Kolja Eppert; Elisa Laurenti; Faiyaz Notta; John E Dick; Giuseppe Basso; Stephen P Hunger; Mignon L Loh; Meenakshi Devidas; Brent Wood; Stuart Winter; Kimberley P Dunsmore; Robert S Fulton; Lucinda L Fulton; Xin Hong; Christopher C Harris; David J Dooling; Kerri Ochoa; Kimberly J Johnson; John C Obenauer; William E Evans; Ching-Hon Pui; Clayton W Naeve; Timothy J Ley; Elaine R Mardis; Richard K Wilson; James R Downing; Charles G Mullighan
Journal: Nature Date: 2012-01-11 Impact factor: 49.962

7. A small-molecule probe of the histone methyltransferase G9a induces cellular senescence in pancreatic adenocarcinoma.

Authors: Yuan Yuan; Qiu Wang; Joshiawa Paulk; Stefan Kubicek; Melissa M Kemp; Drew J Adams; Alykhan F Shamji; Bridget K Wagner; Stuart L Schreiber
Journal: ACS Chem Biol Date: 2012-04-30 Impact factor: 5.100

Review 8. Epigenetic modifications as therapeutic targets.

Authors: Theresa K Kelly; Daniel D De Carvalho; Peter A Jones
Journal: Nat Biotechnol Date: 2010-10 Impact factor: 54.908

Review 9. The role of EZH2 in tumour progression.

Authors: C-J Chang; M-C Hung
Journal: Br J Cancer Date: 2011-12-20 Impact factor: 7.640

10. Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin.

Authors: Ryan D Morin; Nathalie A Johnson; Tesa M Severson; Andrew J Mungall; Jianghong An; Rodrigo Goya; Jessica E Paul; Merrill Boyle; Bruce W Woolcock; Florian Kuchenbauer; Damian Yap; R Keith Humphries; Obi L Griffith; Sohrab Shah; Henry Zhu; Michelle Kimbara; Pavel Shashkin; Jean F Charlot; Marianna Tcherpakov; Richard Corbett; Angela Tam; Richard Varhol; Duane Smailus; Michelle Moksa; Yongjun Zhao; Allen Delaney; Hong Qian; Inanc Birol; Jacqueline Schein; Richard Moore; Robert Holt; Doug E Horsman; Joseph M Connors; Steven Jones; Samuel Aparicio; Martin Hirst; Randy D Gascoyne; Marco A Marra
Journal: Nat Genet Date: 2010-01-17 Impact factor: 38.330

37 in total

Review 1. Histone-modifying enzymes, histone modifications and histone chaperones in nucleosome assembly: Lessons learned from Rtt109 histone acetyltransferases.

Authors: Jayme L Dahlin; Xiaoyue Chen; Michael A Walters; Zhiguo Zhang
Journal: Crit Rev Biochem Mol Biol Date: 2014-11-03 Impact factor: 8.250

Review 2. Therapeutic Targeting of Epithelial Plasticity Programs: Focus on the Epithelial-Mesenchymal Transition.

Authors: Reem Malek; Hailun Wang; Kekoa Taparra; Phuoc T Tran
Journal: Cells Tissues Organs Date: 2017-02-20 Impact factor: 2.481

3. A chemical proteomics approach for global analysis of lysine monomethylome profiling.

Authors: Zhixiang Wu; Zhongyi Cheng; Mingwei Sun; Xuelian Wan; Ping Liu; Tieming He; Minjia Tan; Yingming Zhao
Journal: Mol Cell Proteomics Date: 2014-12-11 Impact factor: 5.911

4. How apoptosis and epithelial-to-mesenchymal transition are nested in EGFR inhibitors resistance in lung cancer.

Authors: Simon Garinet; Audrey Didelot; Elena Garelli; Karine Pallier; Hélène Blons; Antoine Legras
Journal: J Thorac Dis Date: 2019-01 Impact factor: 2.895

5. Structure-guided design of fluorescent S-adenosylmethionine analogs for a high-throughput screen to target SAM-I riboswitch RNAs.

Authors: Scott F Hickey; Ming C Hammond
Journal: Chem Biol Date: 2014-02-20

6. PHF2 histone demethylase prevents DNA damage and genome instability by controlling cell cycle progression of neural progenitors.

Authors: Stella Pappa; Natalia Padilla; Simona Iacobucci; Marta Vicioso; Elena Álvarez de la Campa; Claudia Navarro; Elia Marcos; Xavier de la Cruz; Marian A Martínez-Balbás
Journal: Proc Natl Acad Sci U S A Date: 2019-09-05 Impact factor: 11.205

10. In Vitro and In Vivo Enzyme Activity Screening via RNA-Based Fluorescent Biosensors for S-Adenosyl-l-homocysteine (SAH).

Authors: Yichi Su; Scott F Hickey; Samantha G L Keyser; Ming C Hammond
Journal: J Am Chem Soc Date: 2016-05-27 Impact factor: 15.419