| Literature DB >> 2278102 |
T L Blundell1, R Lapatto, A F Wilderspin, A M Hemmings, P M Hobart, D E Danley, P J Whittle.
Abstract
A proteinase is essential for replication of HIV. Cloning and chemical synthesis have provided a sufficient supply of HIV-1 proteinase for the determination of its three-dimensional structure. Analogies between the structures of HIV-1 proteinase and the mammalian enzyme renin, which is involved in the control of blood pressure, have given important clues concerning the design of specific inhibitors that have antiviral activity.Entities:
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Year: 1990 PMID： 2278102 DOI： 10.1016/0968-0004(90)90280-o
Source DB: PubMed Journal: Trends Biochem Sci ISSN： 0968-0004 Impact factor: 13.807