BACKGROUND: The cause of folliculitis decalvans (FD) remains unknown. We hypothesized that a bacterial biofilm could be involved in its pathogenesis. OBJECTIVE: To assess the presence or not of a bacterial biofilm in the hair roots of the scalp in FD. PATIENTS AND METHODS: Hairs plucked from four patients and three controls were examined by field emission scanning electron microscopy (FESEM) and confocal laser scanning microscopy (CLSM). RESULTS: Bacterial communities organized as biofilms were observed both by FESEM and CLSM in the under infundibular part of hair follicles in all patients and in two of the three controls. In patients and controls, these biofilms were formed exclusively of bacilli of comparable shapes. CONCLUSION: This pilot study provides the first evidence of the presence of bacterial biofilms in the infra infundibular part of human scalp hair follicles. These biofilms were detected both in FD patients and controls, suggesting their ubiquity as a commensal biofilm with a possible pathogenic shift in FD.
BACKGROUND: The cause of folliculitis decalvans (FD) remains unknown. We hypothesized that a bacterial biofilm could be involved in its pathogenesis. OBJECTIVE: To assess the presence or not of a bacterial biofilm in the hair roots of the scalp in FD. PATIENTS AND METHODS: Hairs plucked from four patients and three controls were examined by field emission scanning electron microscopy (FESEM) and confocal laser scanning microscopy (CLSM). RESULTS: Bacterial communities organized as biofilms were observed both by FESEM and CLSM in the under infundibular part of hair follicles in all patients and in two of the three controls. In patients and controls, these biofilms were formed exclusively of bacilli of comparable shapes. CONCLUSION: This pilot study provides the first evidence of the presence of bacterial biofilms in the infra infundibular part of humanscalp hair follicles. These biofilms were detected both in FDpatients and controls, suggesting their ubiquity as a commensal biofilm with a possible pathogenic shift in FD.
Authors: Olivier Lesouhaitier; Thomas Clamens; Thibaut Rosay; Florie Desriac; Mélissande Louis; Sophie Rodrigues; Andrei Gannesen; Vladimir K Plakunov; Emeline Bouffartigues; Ali Tahrioui; Alexis Bazire; Alain Dufour; Pierre Cornelis; Sylvie Chevalier; Marc G J Feuilloley Journal: J Innate Immun Date: 2018-11-05 Impact factor: 7.349
Authors: Daniela Pinto; Francesco Maria Calabrese; Maria De Angelis; Giuseppe Celano; Giammaria Giuliani; Marco Gobbetti; Fabio Rinaldi Journal: Front Cell Infect Microbiol Date: 2020-04-29 Impact factor: 5.293