| Literature DB >> 22779733 |
Yusuke Miura1, Noriyuki Hayashi, Satoshi Yokoshima, Tohru Fukuyama.
Abstract
A first asymmetric total synthesis of (-)-isoschizogamine has been accomplished. Our synthesis features the facile construction of the carbon framework of the natural product through a Wagner-Meerwein rearrangement, a tandem metathesis, a stereoselective rhodium-mediated 1,4-addition of an arylboronic acid, and a ring-closing metathesis via a hemiaminal ether.Entities:
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Year: 2012 PMID： 22779733 DOI： 10.1021/ja305856q
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419