Literature DB >> 22778853

ACS chemical neuroscience spotlight on CEP-1347.

Zachary K Sweeney1, Joseph W Lewcock.   

Abstract

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Year:  2010        PMID： 22778853      PMCID： PMC3369704          DOI： 10.1021/cn1000793

Source DB:  PubMed          Journal:  ACS Chem Neurosci        ISSN： 1948-7193            Impact factor:   4.418


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  8 in total

1.  Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family.

Authors:  A C Maroney; J P Finn; T J Connors; J T Durkin; T Angeles; G Gessner; Z Xu; S L Meyer; M J Savage; L A Greene; R W Scott; J L Vaught
Journal:  J Biol Chem       Date:  2001-04-26       Impact factor: 5.157

2.  Mixed lineage kinase inhibitor CEP-1347 fails to delay disability in early Parkinson disease.

Authors: 
Journal:  Neurology       Date:  2007-09-19       Impact factor: 9.910

3.  Inhibition of the c-Jun N-terminal kinase signaling pathway by the mixed lineage kinase inhibitor CEP-1347 (KT7515) preserves metabolism and growth of trophic factor-deprived neurons.

Authors:  Charles A Harris; Mohanish Deshmukh; Brian Tsui-Pierchala; Anna C Maroney; Eugene M Johnson
Journal:  J Neurosci       Date:  2002-01-01       Impact factor: 6.167

Review 4.  Genetic animal models of Parkinson's disease.

Authors:  Ted M Dawson; Han Seok Ko; Valina L Dawson
Journal:  Neuron       Date:  2010-06-10       Impact factor: 17.173

Review 5.  Discovery of CEP-1347/KT-7515, an inhibitor of the JNK/SAPK pathway for the treatment of neurodegenerative diseases.

Authors:  Michael S Saporito; Robert L Hudkins; Anna C Maroney
Journal:  Prog Med Chem       Date:  2002

6.  JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease.

Authors:  Stéphane Hunot; Miquel Vila; Peter Teismann; Roger J Davis; Etienne C Hirsch; Serge Przedborski; Pasko Rakic; Richard A Flavell
Journal:  Proc Natl Acad Sci U S A       Date:  2004-01-02       Impact factor: 11.205

7.  The safety and tolerability of a mixed lineage kinase inhibitor (CEP-1347) in PD.

Authors: 
Journal:  Neurology       Date:  2004-01-27       Impact factor: 9.910

8.  CEP-1347/KT-7515, an inhibitor of c-jun N-terminal kinase activation, attenuates the 1-methyl-4-phenyl tetrahydropyridine-mediated loss of nigrostriatal dopaminergic neurons In vivo.

Authors:  M S Saporito; E M Brown; M S Miller; S Carswell
Journal:  J Pharmacol Exp Ther       Date:  1999-02       Impact factor: 4.030
  8 in total
  6 in total

1.  Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3.

Authors:  Val S Goodfellow; Colin J Loweth; Satheesh B Ravula; Torsten Wiemann; Thong Nguyen; Yang Xu; Daniel E Todd; David Sheppard; Scott Pollack; Oksana Polesskaya; Daniel F Marker; Stephen Dewhurst; Harris A Gelbard
Journal:  J Med Chem       Date:  2013-10-03       Impact factor: 7.446

Review 2.  Nuclear and cytosolic JNK signalling in neurons.

Authors:  Eleanor T Coffey
Journal:  Nat Rev Neurosci       Date:  2014-05       Impact factor: 34.870

Review 3.  The regulatory function of mixed lineage kinase 3 in tumor and host immunity.

Authors:  Sandeep Kumar; Sunil Kumar Singh; Basabi Rana; Ajay Rana
Journal:  Pharmacol Ther       Date:  2020-10-09       Impact factor: 13.400

4.  Autophagy orchestrates adaptive responses to targeted therapy in endometrial cancer.

Authors:  Núria Eritja; Bo-Juen Chen; Ruth Rodríguez-Barrueco; Maria Santacana; Sònia Gatius; August Vidal; Maria Dolores Martí; Jordi Ponce; Laura Bergadà; Andree Yeramian; Mario Encinas; Joan Ribera; Jaume Reventós; Jeff Boyd; Alberto Villanueva; Xavier Matias-Guiu; Xavier Dolcet; David Llobet-Navàs
Journal:  Autophagy       Date:  2017-01-05       Impact factor: 16.016

Review 5.  Marine-derived protein kinase inhibitors for neuroinflammatory diseases.

Authors:  Chong Ning; Hui-Min David Wang; Rong Gao; Yu-Chia Chang; Fengqing Hu; Xianjun Meng; Shi-Ying Huang
Journal:  Biomed Eng Online       Date:  2018-04-24       Impact factor: 2.819

Review 6.  Compounds from Natural Sources as Protein Kinase Inhibitors.

Authors:  Andrea Baier; Ryszard Szyszka
Journal:  Biomolecules       Date:  2020-11-12
  6 in total

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